Tag: cardiovascular disease

1. Time spent cycling was associated with lower all-cause and cardiovascular disease-specific mortality in this multicenter European cohort study of patients with diabetes, independent of other exercise. 2. Taking up cycling over a five-year period was associated with lower mortality rates compared with those who did not cycle at all. Evidence...
1. The use of coronary artery calcium scoring was associated with significant improvements in the reclassification and discrimination of incident atherosclerotic cardiovascular disease. 2. Coronary artery calcium scoring may be beneficial as an adjunct to risk-enhancing factor assessment when identifying individuals at intermediate risk of atherosclerotic cardiovascular disease who would...
1. Weight loss surgery was associated with significant improvement in both macrovascular and microvascular function across subgroups of sex, race, and metabolic syndrome in addition to effective weight loss. 2. Variation in vascular response to bariatric intervention across subgroups underscores heterogeneity in physiological responses to weight loss and potential activation...
1. In this cohort study, 91% of patients with preserved ejection fraction heart failure had evidence of epicardial coronary artery disease and/or coronary microvascular dysfunction. 2. Due to the high prevalence of these conditions, coronary artery disease and coronary microvascular dysfunction may be unrecognized and underdiagnosed in patients hospitalized with...
1. Retrospective analysis of hospital records showed decreased hospital admission rates for non-COVID-19 diseases in Denmark since the first lockdown. 2. Mortality rates were also shown to be higher for non-COVID-19 diseases, including respiratory diseases, cancer, pneumonia, and sepsis. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has put a...
1. Preventative aspirin was used uniformly by persons with diabetes across age groups, while in persons without diabetes it was used less in young seniors (60-69 and 70-79) and equally in those 80+, potentially outside of clinical recommendations. 2. Based on the results of this study and current guidelines, a...
1. Older patients with polypharmacy who discontinued statins had increased rates of admissions for heart failure, all-cause emergency hospital admissions, cardiovascular outcomes, and all-cause death versus those that did not. Evidence Rating Level: 2 (Good) Study Rundown: With advanced age, patients have multiple comorbidities and are commonly treated with multiple drugs,...
1. Ziltivekimab lowered high-sensitivity CRP levels, a predictor of vascular events, compared to placebo in a dose-dependent manner. 2. Thrombotic biomarkers including fibrinogen, serum amyloid A, haptoglobin, secretory phospholipase A2, and lipoprotein were lower in treatment groups compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Prior studies, including the landmark...
1. Eicosapentaenoic acid (EPA) levels from treatment with omega-3-fatty acids were not associated with changes in cardiovascular (CV) outcomes compared to corn oil placebo, regardless of the plasma EPA level. 2. Higher docosahexaenoic acid (DHA) plasma levels were not associated with an increase in CV events. Evidence Rating Level: 1 (Excellent) Study...
1. Regardless of cardiovascular disease history and baseline blood pressure, a 5 mmHg reduction in systolic blood pressure reduced relative risk of major cardiovascular events by 10%. 2. These findings support considering antihypertensive medications for patients with increased cardiovascular risk, even those who are normotensive at baseline.  Evidence Rating Level: 1...