• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Oral probiotics during pregnancy not linked to preterm delivery

byMaren ShapiroandLeah Hawkins Bressler, MD, MPH
June 26, 2016
in Obstetrics, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. There were no differences in preterm delivery between women randomized to receive an 8-week oral probiotic regimen and those randomized to the control group.

2. There were no differences in vaginal microbiotic health.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Preterm delivery (<37 weeks gestation) accounts for 75 percent of infant mortality and more than 50 percent of long term morbidity. While some preterm deliveries are induced for maternal or fetal reasons, more than two thirds are spontaneous. A common cause of spontaneous preterm birth is thought to be subclinical chorioamnionitis, an infection in the uterus during pregnancy. Imbalances in the vaginal bacterial milieu, known as bacterial vaginosis (BV) may predispose women to developing chorioamnionitis and subsequent preterm delivery. Therefore, there is theoretical benefit to balancing the vaginal microbiota in pregnancy using probiotics, though studies to date were underpowered to assess this outcome. In this randomized, placebo, controlled trial, researchers assessed the effect of commercially available Lactobacilli probiotics on the vaginal microbiota in their first trimester of pregnancy.

After an 8-week oral Lactobacilli probiotic regimen, there was no improvement in vaginal microbiotic health compared to placebo. There was no difference in incidence of preterm delivery between the two groups, though the study was underpowered to detect this difference. Strengths included rigorous design, including triple-blinding. The duration of treatment was only 8 weeks, so although there was no difference found in this study, it’s possible that a longer treatment course could have an impact. Larger studies powered to find a difference in preterm birth are warranted, as well as studies with different probiotic regimen.

Click to read the study in AJOG

Relevant Reading: Vaginal microbiome of reproductive-age women

RELATED REPORTS

Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear

Half-dose antenatal betamethasone is inferior to full dose for preventing usage of neonatal surfactant

Probiotic Bifidobacterium infantis EVC001 associated with decrease in necrotizing enterocolitis

In-Depth [randomized controlled trial]: Pregnant women <12 weeks gestation were randomized to receive either an oral probiotic regimen of Lactobacillus rhamnosus and L. reuteri,(n = 144) or a placebo (n = 148) for 8 weeks. Vaginal swabs taken before and after the intervention were compared according to the Nugent scoring system, an established scoring system for BV. Telephone interviews were also conducted before and after intervention and after delivery. The primary outcome was normal Nugent score (<4) post intervention. Secondary outcomes included intervention-associated side effects, duration of pregnancy, preterm deliveries, and miscarriages.

There was no difference in the rate of preterm delivery between the two groups (3.8% vs. 5.0%, p = 0.59). Following the intervention, the proportion of participants with normal vaginal microbiota decreased from 82.6% to 77.8% (4.8% decline) in the treatment group and from 79.1% to 74.3% (4.8% decline) in the placebo group, with no significant difference across groups (p = 0.297). Symptoms most frequently reported were vaginal discharge and changes in stool consistencies.

Image: CC/Wiki/BobBlaylock

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: preterm deliveryprobiotics
Previous Post

Intrapartum serum prolactin may predict risk of postpartum diabetes

Next Post

Infant motor development may be predictive of childhood cognition

RelatedReports

Probiotics improve colic, reduce GI disorders in infants
Gastroenterology

Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear

September 26, 2022
Digital imaging detects sight-threatening retinopathy of prematurity
Obstetrics

Half-dose antenatal betamethasone is inferior to full dose for preventing usage of neonatal surfactant

August 31, 2022
Probiotics improve colic, reduce GI disorders in infants
Gastroenterology

Probiotic Bifidobacterium infantis EVC001 associated with decrease in necrotizing enterocolitis

January 20, 2022
#VisualAbstract: Probiotics not effective at reducing incidence of ventilator-associated pneumonia in critically ill patients
StudyGraphics

#VisualAbstract: Probiotics not effective at reducing incidence of ventilator-associated pneumonia in critically ill patients

September 29, 2021
Next Post

Infant motor development may be predictive of childhood cognition

Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia

Responsive Parenting intervention linked to improved infant bedtime routines

FDA-approved weight loss medications associated with weight loss at one year

Omega-3 polyunsaturated fatty acids linked to lower mortality from coronary heart disease

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia
  • Plant-based diets may be associated with lower risk of aggressive prostate cancer
  • #VisualAbstract: Adagrasib provides antitumour activity against KRAS G12C mutant metastatic colorectal cancer both as monotherapy and in combination with cetuximab
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options