Tag: preterm delivery

1. Systematic review of RCTs demonstrates reduced rate of early preterm birth (<34 weeks) for high-risk (previous spontaneous preterm birth, short cervix) singleton pregnancies with vaginal progesterone and intramuscular 17-hydroxyprogesterone caproate (17-OHPC). 2. Efficacy of vaginal progesterone and 17-OHPC may be more effective for women with short cervices.  Evidence Rating Level:...
1. Transvaginal cervical length measured at 24 and 28 weeks gestation was inversely associated with risk of spontaneous preterm delivery in a dose-dependent manner. Original Date of Publication: February 1996 Study Rundown: Spontaneous preterm delivery (PTD) is one of the most vexing problems in clinical obstetrics. Currently, over 11% of all...
1. The rate and risk of mortality <28 days from birth was the highest in infants born with both preterm birth (PTB) and small for gestational age (SGA) status, followed by those born with PTB without SGA, then term birth (TB) with SGA (TB-SGA) and TB without SGA. 2....
1. There were no differences in preterm delivery between women randomized to receive an 8-week oral probiotic regimen and those randomized to the control group. 2. There were no differences in vaginal microbiotic health. Evidence Rating Level: 1 (Excellent) Study Rundown: Preterm delivery (<37 weeks gestation) accounts for 75 percent of infant...
1. The birth prevalence of Hirschsprung disease (HSCR) from 1987 to 2012 in Sweden was found to be steady at approximately 1 in 5000 with a male predominance. 2. Significantly more babies with HSCR were born prematurely compared to healthy controls and data suggested maternal obesity as a risk indicator. Evidence...
1. Uterocervical angle (UCA) greater than 95° and 105° were associated with spontaneous preterm birth at <37 weeks and <34 weeks respectively. 2. UCA was more sensitive than cervical length (CL) in predicting preterm birth. Evidence Rating Level: 2 (Good)            Study Rundown: Preterm birth, defined as birth before 37 weeks gestation, complicates...
1. Respiratory distress syndrome (RDS) and perinatal mortality were significantly less common among preterm infants whose mothers received betamethasone prior to delivery. Original Date of Publication: Oct 1972 Study Rundown: Respiratory complications of preterm birth are an important and common cause of preterm morbidity and mortality. Prior to 34 weeks...
1. MicroRNA profiles were not significantly different between women who did and did not experience preterm delivery.  2. Expression of mIR-200a* was decreased in women with preterm birth. Evidence Rating Level: 3 (Average) Study Rundown: Preterm birth, delivery before 37 weeks gestation, impacts over 10% of births in the United States. Risk factors...
Classics Series, Landmark Trials in Medicine
1. Among women with a sonographic short cervix, those randomized to receive daily vaginal progesterone were 45% less likely to experience preterm delivery prior to 33 weeks gestation (NNT=14). 2. Adverse neonatal outcomes including respiratory distress syndrome (NNT=22), low birthweight and neonatal mortality were significantly less common in the vaginal progesterone group. Original...
1. Cervical length was inversely associated with preterm delivery across all gestational age groups.  2. With increasing gestational age, a lower cervical length cut-off value was needed to maximize negative predictive value of delivery within 14 days.  Evidence Rating Level: 2 (Good)             Study Rundown: Various methods of...