• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Hirschsprung disease associated with maternal obesity and preterm birth

bySara RubinandCordelia Ross
June 15, 2016
in Gastroenterology, Obstetrics, Pediatrics, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. The birth prevalence of Hirschsprung disease (HSCR) from 1987 to 2012 in Sweden was found to be steady at approximately 1 in 5000 with a male predominance.

2. Significantly more babies with HSCR were born prematurely compared to healthy controls and data suggested maternal obesity as a risk indicator.

Evidence Rating Level: 3 (Average)

Study Rundown: HSCR is a multifactorial disease caused by an absence of nerve cells in the distal colon or, in the most severe cases, across the entire large intestine. Clinically, this leads to impaired peristalsis, which slows or blocks the passage of stool, resulting in intestinal obstruction and risk for infection. Although multiple susceptibility genes have been identified for HSCR, less is known about the environmental influences. To study the maternal risk factors and infant characteristics associated with HSCR, investigators performed a population-based case-control study in Sweden. The birth prevalence was computed to be 1.91/10 000, and the male-to-female ratio of HSCR cases was found to be 3.7:1. Of the maternal risk factors considered, including maternal age, smoking habits, body mass index (BMI), parity, and diseases (such as diabetes), only maternal obesity was significantly associated with increased risk of HSCR. Additionally, it was found that babies with HSCR were more often born preterm (< 37 weeks’ gestation). Lack of statistical power may have prevented the detection of additional significant associations, particularly with regard to maternal diseases. Further, due to the relatively strict inclusion criteria, it is possible that less severe forms of HSCR were not included. Despite these limitations, this study identifies yet another disease for which obesity may be a risk factor, further emphasizing the importance of addressing this global epidemic.

Click to read the study, published today in Pediatrics

Relevant Reading: Hirschsprung disease, associated syndromes and genetics: a review

In-Depth [case-control study]: Participants included all babies born in Sweden from January 1, 1982 through December 31, 2012 and registered in the Swedish Medical Birth Register (MBR). Data in the MBR included maternal characteristics such as age, height, and weight, in addition to information regarding the pregnancy, such as duration and birth weight. Using unique personal identification numbers, these metrics were linked to pediatric hospital admissions and diagnoses listed in the Swedish National Patient Register (NPR). The inclusion criteria for cases of HSCR required not only HSCR diagnosis, but also a documented HSCR-specific surgical procedure in conjunction with a defined set of pediatric hospital admission requirements. A total of 600 children (466 boys and 134 girls) met these inclusion criteria. For analysis, each case was randomly assigned 5 age- and sex-matched controls. The risk of HSCR was found to be greater among women with BMI ≥30.0 (unadjusted OR = 1.74; 95%CI: 1.25-2.44). Although only trending toward significance in the full analysis, a subanalysis of male cases suggested that parity ≥3 might also be associated with HSCR (male subgroup: unadjusted OR = 1.30; 95%CI: 1.01-1.68). Gestational age <37 weeks was also significantly associated with HSCR diagnosis (unadjusted OR = 1.60; 95%CI: 1.18-2.17). While one might think that caesarean delivery may have been more common in pregnancies of babies with HSCR, no association was found with delivery mode. Additional congenital malformations and/or chromosomal abnormalities were found in 34.5% of the HSCR cases, including 59 individuals (9.8% of the cases) with Down syndrome.

RELATED REPORTS

2 Minute Medicine Rewind January 23, 2023

Weekly semaglutide associated with reduced BMI in adolescents with obesity

Fecal microbiota transplantation not associated with weight loss in bariatric surgery patients

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: body mass index (BMI)Hirschsprung diseasematernal body mass indexobesitypreterm birthpreterm delivery
Previous Post

Hypertensive urgency outcomes similar between outpatient management and hospital referral

Next Post

FDA-approved weight loss medications associated with weight loss at one year

RelatedReports

Many new pediatric asthma cases attributable to obesity
Weekly Rewinds

2 Minute Medicine Rewind January 23, 2023

January 23, 2023
Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization
Chronic Disease

Weekly semaglutide associated with reduced BMI in adolescents with obesity

December 26, 2022
Many new pediatric asthma cases attributable to obesity
Chronic Disease

Fecal microbiota transplantation not associated with weight loss in bariatric surgery patients

December 22, 2022
Late gestation antidepressant use linked to postpartum hemorrhage
Obstetrics

Monofilament suture does not reduce pregnancy loss compared to braided suture for cervical cerclage

December 13, 2022
Next Post
FDA-approved weight loss medications associated with weight loss at one year

FDA-approved weight loss medications associated with weight loss at one year

Government-funded initiatives provide important supports to low-income HIV patients

Neutralizing antibodies protect against SHIV infection in young macaques [PreClinical]

Lariat device for left atrial appendage exclusion associated with adverse events

2 Minute Medicine Rewind June 13, 2016

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Dual antiplatelet therapy discontinued 9 months after percutaneous coronary intervention associated with improved morbidity and mortality
  • Concordance of diagnosis of autism spectrum disorder made by pediatricians vs multidisciplinary specialist teams
  • Cystatin C-based equation without race or sex improves accuracy of GFR estimation
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options