• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Impact of multispecies probiotic in preventing antibiotic-associated diarrhea unclear

byVincent SoandAlex Gipsman, MD
September 26, 2022
in Gastroenterology, Infectious Disease, Pediatrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

 1. In a randomized control trial, administration of multispecies probiotics did not affect the incidence of antibiotic-associated diarrhea as defined by strict criteria.

2. Multispecies probiotic use was associated with a decreased risk of developing diarrhea regardless of etiology and of requiring intravenous rehydration due to diarrhea.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic use. The etiology of AAD is thought to be related to gut dysbiosis which in turn allows overgrowth of pathogenic organisms. There has been mixed evidence regarding the use of probiotics to prevent AAD, with most studies having examined single-species probiotics. This randomized control trial aimed to assess the efficacy of multispecies probiotic in preventing AAD in children aged 3 months to 18 years of age who were receiving antibiotics. AAD was defined as 3 or more loose or watery stools caused by C. Difficle or of unknown etiology. When applying this definition, the rates of AAD were not significantly different between the probiotic and placebo groups. However, the group receiving multispecies probiotics had a lower risk of developing diarrhea regardless of etiology and were less likely to require intravenous rehydration. The decreased overall risk of diarrhea in the probiotics group was largely attributable to less episodes of viral gastroenteritis. A significant number of subjects were lost to follow up, which may have impacted the study’s results. Overall, this study suggests that a multispecies probiotic is ineffective in preventing AAD according to its strict definition, but may be helpful in preventing any cause of diarrhea following use of antibiotics in children.

Click here to read the article in the JAMA Pediatrics

Relevant Reading: Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials

RELATED REPORTS

Probiotic mitigates gut hypoperfusion-associated acute gastrointestinal injury in patients undergoing cardiopulmonary bypass

Probiotic supplementation may improve outcomes in patients with type 2 diabetes

Incidence of C. difficile infections decreasing in hospitalized children

In Depth [randomized controlled trial]: This study was a multicenter, mixed setting (inpatient and outpatient) randomized controlled trial, including participants aged 3 months to 18 years of age who received broad-spectrum antibiotics within 24 hours from 3 Dutch and 2 Polish pediatric sites. Subjects were randomized to two groups of placebo and multispecies probiotic groups, and were instructed to administered the study product within 24 hours of the first antibiotic dose for the duration of the antibiotic treatment and for 7 days after finishing the antibiotic course (maximum 17 days). The multispecies probiotic contained 8 bacterial strains and a dose of 10 billion CFUs daily. Parents recorded the consistency of the subjects’ stool according to the Amsterdam Infant Stool Scale (AISS) or Bristol Stool Form Scale (BSFS). Stool samples were tested for rotavirus, adenovirus, norovirus, Campylobacter, Salmonella, Shigella, and Yersinia and C. difficile. In the study period of Feb 2018 to May 2021, 350 participants were initially randomized, but only 229 completed the study. The primary outcome measure was AAD, defined as 3 or more loose or watery stools in a 24-hour timeframe (with scores of A on the AISS or 5-7 on BSFS) caused by unknown etiology or by C. Difficle following testing for other diarrheal pathogens. When applying this definition, the rates of AAD incidence were not significantly different between probiotic and placebo groups (RR 0.81, 95% CI 0.49-1.33). Interestingly, the multispecies probiotics group did have a lower risk of developing diarrhea regardless of etiology (RR 0.65, 95% CI 0.44-0.94, p=0.02) and were less likely to require intravenous rehydration as a result of diarrhea (number needed to benefit = 32, 95% CI 14-125, p=0.03). This was largely attributable to differences in rotavirus infections between the two groups.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: antibiotic-associated diarrheaC. difficilegastroenteritisprobioticsrotavirus
Previous Post

Regular physical activity may confer protection against adverse COVID-19 outcomes

Next Post

Selpercatinib continues to demonstrate effective response in RET fusion-positive NSCLC

RelatedReports

Parental nonmedical prescription opioid use linked to adolescent use
Cardiology

Probiotic mitigates gut hypoperfusion-associated acute gastrointestinal injury in patients undergoing cardiopulmonary bypass

May 19, 2025
Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization
Cardiology

Probiotic supplementation may improve outcomes in patients with type 2 diabetes

January 14, 2024
Quick Take: Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials
Chronic Disease

Incidence of C. difficile infections decreasing in hospitalized children

September 5, 2022
Probiotics improve colic, reduce GI disorders in infants
Gastroenterology

Multispecies probiotic reduces overall risk of diarrhea in antibiotic-treated children

July 13, 2022
Next Post
Oophorectomy associated with reduced cancer risk and all-cause mortality for BRCA1/2 patients

Selpercatinib continues to demonstrate effective response in RET fusion-positive NSCLC

Differential RNA expression in late onset fetal growth restriction

Selpercatinib showed promising clinical activity in tumour-agnostic patients with RET­ fusion-positive cancers other than thyroid and lung cancer

Insulin costs rose exponentially, regardless of formulation or patent

Glargine and liraglutide are effective glucose-lowering medications in type 2 diabetes

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Fecal microbiota transplantation may be more effective than vancomycin in treating primary C. difficile infection
  • Frailty scores alone may be poor predictors of intensive care admission or hospital stay duration
  • Anal cancer screening cost-effective for men who have sex with men with human immunodeficiency virus aged above 35 years
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.