Tag: C. difficile

Effect of Oral Capsule – vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection The most efficacious means of reducing recurrent clostridium difficile infection (RCDI) is by way of fecal microbiota transplantation (FMT). It is unclear, however, whether clinical efficacy varies with route of delivery, either by colonoscopy or oral capsule....
1. Using frozen versus fresh fecal microbiota transplants for patients with recurrent or refractory Clostridium difficile infection resulted in similar rates of resolution of diarrhea at 13 weeks of follow-up. 2. Both frozen and fresh fecal microbiota transplantation had similar rates of adverse events after 13 months of follow-up. Evidence Rating Level: 1...
1. Based on this prospective cohort study, only half of the patients who tested positive for the Clostridium difficile (C. difficile) polymerase chain reaction (PCR) also tested positive for the toxin (Tox), and the patients who were tox negative and PCR positive (Tox-/PCR+) had diarrhea that was less severe,...
1. In this study, spores of non-toxigenic Clostridium difficile (C. difficile; M3 strain) administered for prevention of recurrent C. difficile infection were generally well tolerated with adverse events occurring in only 3% of individuals receiving this intervention. 2. Rates of recurrent C. difficile infection were lower in individuals receiving non-toxigenic...
1. Patients on continuous proton pump inhibitor (PPI) had an increased risk of recurrence of their Clostridium difficile infection. 2. While PPI use was common, almost half of patients did not have an evidence-based indication for usage. Evidence Rating Level: 2 (Good) Study Rundown: Preventing recurrence of Clostridium difficile infection (CDI) is...
1. The reduction of the gut bacterium, C. scindens, following antibiotic treatment was correlated with increased risk of C. diff in both mice and humans, and the transfer of this bacterium was linked to reduced C. diff infection in antibiotic-exposed mice. 2. The abundance of secondary bile acid, which requires...
Classics Series, Landmark Trials in Medicine
1. Treating recurrent C. difficile infection with infusion of donor feces resulted in significantly higher cure rates than treating with vancomycin-alone or vancomycin with bowel lavage. 2. Adverse events immediately after feces infusion included diarrhea, cramping, and belching. Original Date of Publication: January 31, 2013 Study Rundown: Previous studies have demonstrated that...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing Clostridium difficile is responsible for diarrhea and colitis in many patients undergoing antibiotic treatment. Many healthcare facilities have protocols for isolation and...
Image: PD  1. The majority of Clostridium difficile infections were transmitted from sources other than symptomatic patients.  2. Genetically distinct isolates of Clostridium difficile suggest diverse sources of infection.  Evidence Rating Level: 2 (Good) Study Rundown: Current measures in preventing Clostridium difficile infections are based on the thought that most infections are transmitted...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial Microbial preparations have been proposed as a...