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Maternal anti-epileptic use linked to autism disorders in offspring

...ly neural tube defects, and more recent evidence has suggested a potential link to childhood autism and other ASDs. The authors’ findings are the first from a large-scale, population-based study to provide support to this notion. As a population-based study, this investigation relies on the integrity of the Danish Civil Registry System, which has only an 81% positive predictive value for determining a maternal epilepsy diagnosis. Moreover, the stu...

Longer-duration breast feeding not associated with lower risk of obesity in childhood

...underscore the importance of further investigation into other causative factors. Click to read the study in JAMA [/tab] [tab] Image: PD 1. Limited evidence has suggested longer and exclusive breastfeeding in infancy may lower the risk of later childhood obesity while still promoting growth. 2. In fact, when examined in late childhood, children who received more exclusive and/or longer term breastfeeding had similar growth and body fat profiles. Th...

New mutations behind heritable hypercalcemia and hypocalcemia identified

...Protein modeling suggests that the mutations inhibit the enzyme’s ability to transition to its active state. The authors were also able to find missense mutations in Gɑ 11 in two patients with hypocalcemia. In vitro studies showed that these mutations increased the sensitivity of cells to extracellular calcium – a gain of function. Protein modeling suggests that the mutations prolong the time Gɑ 11 spends in its active GTP-bound state. This study...

Meta-analysis supports Institute of Medicine’s vaccine safety findings

...measles/mumps/rubella (MMR) vaccine is not linked to autism but that it is linked to a risk of febrile seizures. 2. There is moderate evidence that links the rotavirus vaccination to a risk of intussusception and the hepatitis A vaccine to purpura. 3. There is strong evidence that vaccinations are not associated with childhood leukemias. Evidence Rating Level: 2 (Good) Study Rundown: Immunizations have significantly reduced the incidence of infect...

Increased diabetes risk observed in gout patients

...in men with gout and cardiovascular risk factors, this is the first study to show a link between gout and increased diabetes in a large, heterogeneous cohort of men and women. While this study was not able to comment on the effect of dietary factors, such as sugar drink intake, a clear link between gout and increased diabetes risk was thoroughly established. A follow up prospective cohort study would help validate the findings of this case-contro...

Proton pump inhibitor use associated with development of chronic kidney disease

...most prescribed medications, often without a strong indication, have been linked to acute kidney injury (AKI). The theory is that recurrent bouts of AKI may lead to CKD. This study, which used data from two prospective cohorts, was conducted to evaluate the link between PPIs and incident CKD. The results of the study showed that use of proton pump inhibitors (PPIs) was associated with about 20 – 50% higher risk of developing chronic kidney diseas...

Risk-reduction counseling with HIV testing may not decrease rates of sexually transmitted infections

...ogy and duration associated with cardiac resynchronization outcomes, New genetic link between type 2 diabetes and coronary heart disease, Repeat bone mineral density testing may not improve prediction of fracture outcomes © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No p...

[CANCER] Marijuana associated with increased risk of germ cell and nonseminoma testicular cancer

...d to conduct a large study, controlling for various demographic factors in order to better elucidate a relationship. This [case-control] study: Cases (163) and controls (292) were matched on age, race and neighborhood and drug use at time of diagnosis was ascertained via patient interview. While cases had a higher history of cryptorchidism, a known risk factor for testicular cancer – this was adjusted for in the analysis as well as use of cocaine...

Repeat bone mineral density testing may not improve prediction of fracture outcomes

...ogy and duration associated with cardiac resynchronization outcomes, New genetic link between type 2 diabetes and coronary heart disease © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors,...

Peer victimization and emotional distress among LGB youth

...ional distress among LGB youth relative to heterosexual youth has a strong link to victimization and bullying, but is not the sole cause. This study employs a longitudinal prospective design to both characterize the incidence of victimization for LGB youth and to evaluate how this victimization contributes to their emotional health. Although these data are limited by self-report of victimization and qualitative evaluations of emotional distress, i...

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