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USPSTF finds insufficient evidence for thyroid screening

...id medication prescription in the U.S. have increased more than 40% between 2006 and 2010. This report was commissioned to build on previous reviews on subclinical thyroid disease, and it differs from past publications by addressing identification and treatment of undiagnosed overt thyroid disease. From this review, no direct evidence on the effects of thyroid screening versus no screening on clinical outcomes was identified. Treatment of subclini...

Mobile text messaging may improve medication adherence

...bias was assessed in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Statistical analysis included assessment of effect size to pool estimates, I2 statistic for heterogeneity, and publication bias funnel plot assessment. Of the 44 full-text reviews, 16 RCTs met inclusion criteria for the final meta-analysis, which represented over 2,700 patients. The median sample size was 97 and studies evaluated various chronic di...

2 Minute Medicine Rewind October 20 – October 27, 2014

...o 4.5 million patients covered by HMO insurance plans in California between 2009 and 2012, and compared the total annual expenditures per patient (as determined by insurance payments and including payments to practicing physicians, hospitals, clinical laboratories, and pharmaceutical manufacturers for office visits, inpatient and outpatient procedures, diagnostics tests, and pharmaceuticals). The total expenditures were also adjusted for patient i...

Chest radiograph neural network predicts lung cancer in smokers

...y to non-smokers. In summary, this study demonstrated that a deep-learning network based on electronic health data is comparable to current high performing models without smoking history as an input. Click here to read the study, published today in Annals of Internal Medicine Relevant Reading: Selection Criteria for Lung-Cancer Screening In-Depth [retrospective cohort]: This study trained a neural network using the PLCO (Prostate, Lung, Colorectal...

USPSTF recommends routinely screening asymptomatic women for chlamydia and gonorrhea

...hat screening of pregnant women to avoid ophthalmia neonatorum provided no net benefit because universal ocular prophylaxis of newborns is very effective and the prevalence of infection is low in this group. Screening for both chlamydia and gonorrhea should be done simultaneously using the highly sensitive nucleic acid amplification tests (NAATs). Click to read the study, published today in AIM Relevant Reading: Recommendations for the laboratory-...

Nusinersen improves motor function in children with later-onset spinal muscular atrophy: The CHERISH trial

...is multicenter, phase 3, double-blind, sham-controlled study conducted from 2014 to 2017 randomized 126 patients into two treatment arms based on a 2:1 ratio: nusinersen (n = 84) or placebo (n = 42). Eligible patients had genetic SMA documentation, symptom onset after 6 months of age, and were 2 to 12 years old. Excluded patients had severe contractures or scoliosis, or respiratory insufficiency. Both groups received scheduled 12mg intrathecal adm...

Intervention to reduce low-value preoperative care for patients undergoing cataract surgery

...rom physician leadership to clinicians. The quality improvement nurse spent 20% of her time leading the initiative for one year. Primary outcome was percentage of patients with preoperative medical visits, chest x-rays, laboratory tests, or electrocardiograms within 80 days of surgery. Secondary outcomes included serious 30-day postoperative adverse events (e.g. myocardial infarction, stroke, or hypoglycemia). A cost analysis was also performed. C...

Global surveillance of cancer trends reveals wide variances in survival rate [CONCORD-2 study]

...to middle-income countries alike, with 5-year survival typically less than 20%. Cervical cancer 5-year survival varied from 50% to 70%, demonstrating a potential disparity in screening and management of a largely preventable disease. More from this author: START intervention for dementia caregivers linked to reduction of depression symptoms, Mechanical CPR provides no benefit over manual CPR [PARAMEDIC trial], Group B streptococcus infections on...

Physicians report feeling moral distress over hospital policies that force inadequate care based on...

...has several limitations. First, the study was conducted in only two safety net systems, and it may not be applicable to other training environments. Furthermore, there may have been an inherent response bias from participants, where negative experiences and perceptions were minimized due to social desirability. Strengths of this study include that it looked to evaluate clinicians’ experiences with this policy, rather than only the patients’ experi...

2 Minute Medicine Rewind December 31, 2018

...study therefore shows that in premenopausal women receiving letrozole for NET, OFS is achieved more quickly and sustained more effectively with the use of degarelix as compared to triptorelin. Risk of depression and anxiety in adults with cerebral palsy The motor disturbances seen in patients with cerebral palsy (CP) may also be comorbid with other issues including behavioural disturbance, cognitive difficulties, sensory impairments, epilepsy and...

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