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Proton pump inhibitor use associated with development of chronic kidney disease

...showed that use of proton pump inhibitors (PPIs) was associated with about 20 – 50% higher risk of developing chronic kidney disease (CKD). This same risk was not present with the use of H2-antagonists, which are prescribed for the same indications as PPIs. The strength of this study was the use of two prospective cohorts to evaluate the relationship between PPIs and CKD, which strengthens the validity of the results. Drawbacks are the observatio...

Experimental malaria vaccine confers modest, short-term protection

...d. The authors calculated that the numbers of malaria cases prevented per 100 children vaccinated in each year of follow-up were: 26, 22, 18 and -1. The incidence rate of malaria episodes in year four was the same in the vaccinated and control groups. The efficacy of the vaccine over four years was also affected by intensity of malaria exposure. In the high exposure index group, the vaccinated and unvaccinated groups both had a similar incidence o...

Meta-analysis supports Institute of Medicine’s vaccine safety findings

...and AEs published in the scientific literature, including evidence from the 2011 Institute of Medicine (IOM) report, Adverse Effects of Vaccines. Results supported IOM findings of strong evidence that the measles/mumps/rubella (MMR) vaccine is not associated with autism, though it is associated with a risk of febrile seizures. A moderate association was found between both the live attenuated and trivalent influenza vaccine formulations and mild ga...

New mutations behind heritable hypercalcemia and hypocalcemia identified

...cupuncture helpful for chronic pain: new meta-analysis [Arch Intern Med.] © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA...

Longer-duration breast feeding not associated with lower risk of obesity in childhood

...iretroviral therapy linked with lower risk of cognitive impairment in HIV © 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA...

Maternal anti-epileptic use linked to autism disorders in offspring

...ional study]: The authors assessed all children born in Denmark from 1996-2006 (n=655,615) for in utero AED exposure and current diagnoses of autism spectrum disorders. Of these, 2,644 children were exposed to AEDs, 508 of which were exposed to valproate. Additionally, 5,437 were diagnosed with autism spectrum disorders, 2,067 of these involved childhood autism. In children exposed to valproate in utero, the absolute risks of childhood autism and...

Physical exercise associated with reduced risk of chronic pain in University students

...ery day lowered the risk for chronic pain the most (OR = 0.79, 95% CI = 0.70-0.88). The strength of these findings were only minimally impacted after adjusting for lifestyle factors, such as alcohol consumption and amount of sleep. The findings of this study show the potential for post-secondary schools to incorporate physical exercise into student life, in order to combat the chronic pain that is often associated with sedentary student behaviours...

World Trade Center rescue workers have an increased incidence of multiple myeloma, thyroid, and...

...for cancer and include air pollution such as smoke, dust and aerosols. In 2001, the September 11th terrorist attacks on the World Trade Center (WTC) in New York City claimed many lives and exposed thousands of rescue workers, bystanders, and residents to dust, debris, and potentially toxic building materials. In this study, the authors investigated the cancer risk among rescue workers and bystanders in order to determine the incidence and types of...

Soaring rates of peripheral artery disease, now over 200 million cases worldwide

...valence of peripheral artery disease (PAD) has increased by 23.5% between 2000 and 2010, and now affects over 202 million people globally. 2. More than two-thirds of people living with PAD live in low- and middle-income countries. 3. Change in PAD prevalence is greatest in those older than 80 years of age, with a rise of more than 35% in one decade. Evidence Rating Level: 1 (Excellent) Study Rundown: Lower limb peripheral artery disease (PAD) is t...

3D mammography (tomosynthesis) enhances accuracy of breast cancer screening

...omosynthesis. A decrease in recall rate was of -16 (95%CI, -18 to -14; P< .001) per 1000 screens was observed for the later group. The percentage of biopsies were also an increased in the digital mammography plus tomosynthesis group (3285 (19.3%) vs. 5056 (18.1%)). This represents an increased rate of 1.3 biopsies per 1000 screens. An increase in cancer detection rate of 1.2 (95% CI, 0.8-1.6; P< .001) per 1000 was also observed for the digital mam...

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