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Home The Classics Pediatrics Classics

PECARN Prediction rules for children at a low risk of clinically-important traumatic brain injury [Classics Series]

byDeepti Shroff Karhade
September 22, 2022
in Pediatrics Classics, The Classics
Reading Time: 3 mins read
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This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials

1. The absence of 6 established predictors was found to have a near 100% negative predictive value (NPV) for clinically-important traumatic brain injury (ciTBI) when applied to head trauma patients under 18 years of age.

2. An algorithm was proposed, applying these predictors, in order to prevent physicians from using unnecessary computed tomography (CT) in pediatric patients at low risk for ciTBI.

Original Date of Publication: September 2009

Study Rundown: TBI continues to be one of the leading causes of morbidity and mortality among the pediatric population. At the time of this study, CT was the standard imaging technique for identifying TBI patients requiring intervention after head trauma. However, given the increase in malignancy risk associated with CT scans, investigators of this trial sought to identify patients at a low risk for ciTBI to potentially reduce CT imaging. Through the use of a large study cohort from various emergency departments, researchers analyzed the NPVs and sensitivities associated with a proposed “prediction rule”, defined as having none of the identified ciTBI predictors versus having any cTBI predictors. The NPV and sensitivity of this prediction rule was then analyzed. Researchers found a NPV of > 98% and sensitivity > 94% in the prediction of ciTBI and TBI-negative CT scans in participants of all ages. Despite the fact that researchers did not CT scan all participants and sensitivities were not found to be 100%, this large, adequately powered study found similar results among both derivation and validation participant groups. With their findings, researchers were able to construct algorithms guiding physicians on appropriate CT scans use in head-injured patients. Altered mental status (AMS) and signs of skull fracture were established as branching points for patients at highest risk for ciTBI.

Click to read the study in The Lancet

In-Depth [prospective cohort]: Data was analyzed from 42 412 patients under 18 years of age (mean 7.1 years +5.5) who had experienced blunt head trauma within 24 hours from presentation and had Glasgow Coma Scale scores of 14-15. Patients were divided into derivation (n = 33 785) and validation groups (n = 8627) by recruitment date. ciTBI was defined as TBI-related death, need for neurosurgical intervention, intubation for more than one day following injury, or hospital admission for 2 or more nights. Research coordinators reviewed patient records during hospital admissions and completed telephone surveys of patient guardians for follow-up of patients discharged within 90 days of their ED visit. Predictors were chosen based upon established selection criteria and analyses were run to account for baseline development-related radiation risk with children under 2 years of age analyzed separately from those above 2 years of age.

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Predictors for children under 2 years of age included: AMS, scalp hematoma, loss of consciousness (LOC), significant mechanism of injury (MOI), potential skull fracture, and changes in behavior. Predictors for those older than 2 years old included: AMS, LOC, vomiting, significant MOI, signs of basilar skull fracture, and headache. The number of predictors and risk of ciTBI in the derivation and validation groups were then compared. A total of 14 696 (35.5%) of participants underwent CT scan. Of these patients, 780 (5.2%) were found to have TBI on imaging and 376 (0.9%) with ciTBI (15.9% required surgical intervention, 0.02% required intubation for more than one day, 0% died from their injury). Among children under 2 years of age in the validation group, the prediction rule had an NPV of 100% and sensitivity of 100% for ciTBI. Among children over 2 years of age, this prediction rule had an NPV of 99.95% and sensitivity of 96.8% for ciTBI. In addition, among children under 2 years of age, the prediction rule had an NPV of 100% and sensitivity of 100% for patients having CT scan without evidence of TBI. Among children older than 2 years of age, the prediction rule had an NPV of 98.4% and sensitivity of 94% for patients having CT scans without evidence of TBI.

Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, et al. Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet. 2009 Oct 3;374(9696):1160–70.

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

Tags: CT scanpredictive modelingtraumatic brain injury
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