• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Ophthalmology

Preterm birth associated with differences in optic disc morphology in adulthood

byMolly MunsellandDeepti Shroff Karhade
May 9, 2022
in Ophthalmology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a cohort of approximately 750 eyes of 400 adults, vertical cup-to-disc ratio (VCDR) was significantly increased for individuals born before 28 weeks compared to those born at full term.

2. History of retinopathy of prematurity (ROP) was not associated with a difference in VCDR.

Evidence Rating Level: 2 (Good)

Study Rundown: Retinopathy of prematurity (ROP) is a common complication of preterm birth. Initial hyperoxia due to oxygen supplementation and neonatal changes induces dysregulated vascular proliferation in the retina. Outcomes of ROP beyond early childhood are currently poorly understood. The Gutenberg Prematurity Eye Study examined a cohort of German adults born prematurely with and without a history of ROP. In this study, optic nerve head morphology was assessed as a marker for enduring central nervous system changes as well as potential predisposition to glaucoma. Optic disc metrics were measured using fundus photography then compared between 74 eyes of individuals born preterm with ROP, 413 without ROP, and 256 of controls born at full-term. Vertical cup-to-disc ratio (VCDR) was significantly higher in patients born at or before 28 weeks gestation without ROP and with untreated ROP than in the control group. The 5 patients with ROP who had been treated with laser or cryo-coagulation had significantly smaller VCDR than controls and were more likely to have torted discs, although interpretation is limited by the small subgroup size. In an adjusted model, lower gestational age, birth weight, and birth weight percentile were all significantly associated with decreased VCDR. The occurrence of ROP was not associated with any difference in VCDR. Though fewer patients with ROP were included, this study indicates that extreme prematurity is associated with increased cup-to-disk ratio while ROP itself is not. It seems possible that some portion of the patients born before 28 weeks suffered from undiagnosed ROP, leading to a confounding effect. Further study of the implications of these morphological differences for glaucoma risk is called for, especially as the percentage of the population born premature and extremely premature increases.

Click to read the study in AJO

Relevant Reading: Retinopathy of prematurity

In-Depth [retrospective cohort]: Adults aged 18 to 52 years who had been born at a single center were included. Controls born at full-term, defined as 37 weeks or later, were not demographically matched to preterm subjects. Non-dilated fundus photographs were taken at 30° and 45° to the optic nerve head. Optic disc dimensions were measured manually using ImageJ and corrected for ocular magnification. Discs with a torsion angle greater than 15° were considered torted, while discs with a ratio <0.8 between short and long diameters were considered tilted. Macula-disc angle did not differ between most of the groups stratified by gestational age. Analysis for associations with VCDR was performed after adjusting for age, sex, spherical equivalent, and optic disc dimensions. No significant association between VCDR and potential prenatal or perinatal risk factors, including preeclampsia, placental insufficiency, or maternal smoking, was observed. The torsion angle was significantly lower in patients whose mothers had preeclampsia and in patients who received treatment for ROP.

RELATED REPORTS

Enteric administration of recombinant human insulin to preterm infants is safe and effective

Cervical intraepithelial neoplasia grade 3 associated with adverse pregnancy outcomes

Extreme prematurity associated with increased prevalence of visual and ocular deficits in young adults

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: fundusoptic discpreterm birthretinopathy
Previous Post

Treatment with chemoradiotherapy before systemic chemotherapy for rectal adenocarcinoma is a potential non-surgical option

Next Post

An implantable system overcomes orthostatic hypotension in a patient with multiple-system atrophy

RelatedReports

Neonatal neuroimaging with strong negative predictive value for developmental outcomes: The NEURO study
Pediatrics

Enteric administration of recombinant human insulin to preterm infants is safe and effective

April 4, 2022
5-FU a promising treatment for CIN-2
Chronic Disease

Cervical intraepithelial neoplasia grade 3 associated with adverse pregnancy outcomes

February 22, 2022
Low evidence for glycerin use in preterm infants
Chronic Disease

Extreme prematurity associated with increased prevalence of visual and ocular deficits in young adults

January 31, 2022
Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia
Obstetrics

Trends in morbidity and mortality of extremely preterm infants in the United States

January 20, 2022
Next Post
Increased number of daily steps linked with decreased mortality in older women

An implantable system overcomes orthostatic hypotension in a patient with multiple-system atrophy

Complement mutation linked to poor response to eculizumab

Mitapivat efficacious in treating pyruvate kinase deficiency

Combined MRI and NIH stroke scores may predict stroke prognosis

Green Mediterranean diet reduced age-related brain atrophy

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.