• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Quick Take: Diagnostic Yield of One-Time Colonoscopy vs One-Time Flexible Sigmoidoscopy vs Multiple Rounds of Mailed Fecal Immunohistochemical Tests in Colorectal Cancer Screening

byDonna LeetandAliya Ramjaun
August 28, 2019
in Gastroenterology, Oncology, Public Health
Reading Time: 2 mins read
1
Share on FacebookShare on Twitter

RELATED REPORTS

Video capsule endoscopy is safe and effective in the initial evaluation of acute gastrointestinal bleeding during the COVID-19 pandemic

Shortened duration of adjuvant chemotherapy in individuals with stage III colon cancer may be associated with noninferior overall survival

#VisualAbstract: Pembrolizumab linked to longer cancer-free period in advanced MSI-H-dMMR colorectal cancer

The most common colorectal cancer (CRC) screening methods are colonoscopy, flexible sigmoidoscopy (FS), and fecal immunochemical testing (FIT). The diagnostic yield of any screening method is dependent on participation, and endoscopic screening consistently shows lower participation rates compared to FIT-based screening. In this analysis of three randomized studies, 30,052 asymptomatic patients aged 50 to 74 years were invited for CRC screening and assigned to either 4 rounds of FIT (15,046 patients invited), once-only FS (8,407 patients invited), or once-only colonoscopy (6,600 patients invited), to determine the number of advanced neoplasias (AN) detected with each test. Patients with positive FIT results (≥10 μg Hb/g feces), or FS patients found to have a polyp ≥10 mm, adenoma with ≥25% villous histology or high-grade dysplasia, sessile serrated adenoma, ≥3 adenomas, ≥20 hyperplastic polyps, or invasive CRC were referred for colonoscopy. Researchers found that the participation rate was significantly higher for FIT screening (77%) than for FS (31%, p<0.001) or colonoscopy (24%, p<0.001). In the intention-to-screen analysis, the cumulative diagnostic yield of AN was higher with FIT screening (4.5%, 95% CI 4.2% to 4.9%) than with colonoscopy (2.2%, 95% CI, 1.8% to 2.6%) or FS (2.3%, 95% CI, 2.0% to 2.7%). In the as-screened analysis, colonoscopy detected more AN (9.1%, 95% CI 7.7% to 10.7%) than FS (7.4%, 95% CI 6.5% to 8.5%) and FIT (6.1%, 95% CI 5.7% to 6.6%). However, CRC detection rates were similar for FIT (0.8%, 95% CI 0.6% to 0.9%), FS (0.5%, 95% CI 0.3% to 0.9%) and colonoscopy (0.6%, 95% CI 0.3% to 1.2%). Among invitees, the rate of interval CRC development was 0.13% in patients with a negative result from the FIT, 0.09% in patients with a negative result from flexible sigmoidoscopy, and 0.01% in patients with a negative result from colonoscopy. A limitation of this study was that those invited for primary endoscopic screening were only invited once, as compared with those screened with FIT who were approached biennially, which may have impacted participation rates. In summary, this study suggests that FIT screening has a higher diagnostic yield for AN compared to endoscopic screening, despite significantly fewer colonoscopies.

Click to read the study in Clinical Gastroenterology and Hepatology

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: colon cancercolonoscopyfecal immunochemical testsflexible sigmoidoscopy
Previous Post

FDG-PET scanning demonstrates prognostic significance in prosthetic valve infective endocarditis

Next Post

#VisualAbstract: Trial of Galcanezumab in Prevention of Episodic Cluster Headache

RelatedReports

Patient Basics: Colonoscopy
Emergency

Video capsule endoscopy is safe and effective in the initial evaluation of acute gastrointestinal bleeding during the COVID-19 pandemic

August 2, 2021
Racial differences in colorectal cancer survival linked to health at initial diagnosis
2 Minute Medicine

Shortened duration of adjuvant chemotherapy in individuals with stage III colon cancer may be associated with noninferior overall survival

June 2, 2021
#VisualAbstract: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction
Chronic Disease

#VisualAbstract: Pembrolizumab linked to longer cancer-free period in advanced MSI-H-dMMR colorectal cancer

January 28, 2021
#VisualAbstract: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction
StudyGraphics

#VisualAbstract: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction

January 24, 2021
Next Post
#VisualAbstract: Trial of Galcanezumab in Prevention of Episodic Cluster Headache

#VisualAbstract: Trial of Galcanezumab in Prevention of Episodic Cluster Headache

Quick Take: Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes

Quick Take: Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes

Quick Take: Influence of HIV Infection on the Natural History of Hepatocellular Carcinoma: Results From a Global Multicohort Study

Lipophilic statins associated with reduced risk for hepatocellular carcinoma

Please login to join discussion

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Sensorimotor retraining improves pain intensity in patients with chronic lower back pain
  • LI-RADS outlines standards for liver imaging studies assessing HCC [Classics Series]
  • Daily disposable contact lenses may lower risk for Acanthamoeba keratitis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.