While a gluten-free diet is indicated in patients with clinical gluten sensitivity (GS), including celiac disease, there continues to be growing interest in adopting a gluten-free diet (GFD) amongst the general population. This has been largely perpetuated by a belief that a GFD is generally healthier. In this double-blind randomized controlled trial, 28 patients with no previously diagnosed gluten-related disorders were educated and commenced on a GFD. Participants were subsequently randomized to add a flour sachet containing either an organic gluten or a gluten-free blend to their diet, twice daily, to determine whether a GFD was associated with a decreased incidence of gastrointestinal symptoms. Subjects completed Gastrointestinal Symptom Rating Scales to measure baseline abdominal pain, reflux, indigestion, diarrhea, and constipation. Researchers found no significant differences in change of any symptom between the two study arms. This study therefore shows that the consumption of gluten-containing flour does not generate symptoms in healthy individuals without gluten-related disorders.
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