Tag: celiac disease

1. ZED1227, a selective oral transglutaminase 2 inhibitor, was shown to reduce gluten-induced deterioration of intestinal mucosa in patients with celiac disease. 2. No significant differences in adverse events were experienced between experimental groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Patients with celiac disease express higher than normal levels of transglutaminase...
1. In middle-aged women without celiac disease, there is no significant association between gluten intake and cognitive function across quintiles of gluten intake. 2. Further stratification by potential confounding factors such as age, smoking status, and history of diabetes also yielded null results. Evidence Rating Level: 2 (Good)         In patients...
2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series dedicated to exploring new research evidence focused on wellness. Each week, we will report on articles examining different aspects of wellness, including (but not limited to) nutrition, sleep, reproductive health, substance use and...
1. In a small cohort of patients, IL-2 elevation after gluten challenge appears to be the earliest and most sensitive marker of gluten exposure and may play a role in non-invasive diagnostics of celiac disease in the future. Evidence Level Rating: 2 (Good) Celiac disease (CeD), an immune-mediated disorder, has an...
While a gluten-free diet is indicated in patients with clinical gluten sensitivity (GS), including celiac disease, there continues to be growing interest in adopting a gluten-free diet (GFD) amongst the general population. This has been largely perpetuated by a belief that a GFD is generally healthier. In this double-blind...
Originally published by Harvard Health. What Is It? Celiac disease (also called non-tropical sprue, celiac sprue, gluten intolerance and gluten-sensitive enteropathy) is an intestinal disorder in which the body cannot tolerate gluten. Gluten is a natural protein in many grains, including wheat, barley, rye and oats. People with celiac disease have an...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury Patients with traumatic brain injury (TBI) commonly develop anemia, which can cause secondary injury and worsen neurological outcomes. Erythropoietin has...
1. Children with the HLA haplotype DR3-DQ2 were at a higher risk for developing celiac disease autoimmunity and celiac disease by 5 years of age. 2. Female gender, Swedish residence, and having a first-degree relative with celiac disease were associated with a higher risk of developing celiac disease autoimmunity. Evidence Rating...
Image: CC/Wiki 1. The prevalence of celiac disease in children with Irritable bowel syndrome (IBS) was found to be four times higher as compared to the general population.  Evidence Rating Level: 1 (Excellent)     Study Rundown: Recurrent abdominal pain in school-aged children results in a large number of visits to the...
Image: PD  1. In a cohort of children, delayed gluten introduction at >6 months of age was associated with a significantly increased risk of Celiac disease that was not seen in those with earlier introductions.  2. A notable, yet not statistically significant, increased risk of Celiac disease was seen in infants...