• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Risk of all-cause and cause-specific mortality increased for women with type 1 diabetes

byMelissa McCoyandXiaozhou Liu
February 8, 2015
in Chronic Disease, Endocrinology, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. When compared to men with type 1 diabetes, women have a 37% greater excess risk of all-cause mortality

2. When compared to men with type 1 diabetes, women have twice the excess risk of fatal and nonfatal vascular events

Evidence Rating Level: 1 (Excellent)      

Study Rundown: Type 1 diabetes is a common, chronic autoimmune disorder that affects men and women with an equal incidence. Despite this, sex differences in excess mortality have been documented. This meta-analysis is the first to quantify sex difference in all-cause mortality and cause-specific mortality associated with type 1 diabetes. Documentation of a clinically meaningful sex difference in risk holds implications for the development of focused management strategies. Differences in mortality between men and women with type 1 diabetes were assessed by all cause mortality, mortality from cardiovascular disease, renal disease, the combined outcomes of accident and suicide, cancer, and from incident coronary heart disease and stroke associated with type 1 diabetes. Excess risk for all-cause mortality was 37% higher in women than men with type 1 diabetes. In analysis for cause-specific mortality, women demonstrated a 154% greater excess event rate for coronary heart disease, a 44% excess risk of renal mortality, and a 27% greater excess event rate for fatal and non-fatal stroke when compared to men with type 1 diabetes. No significant sex difference in risk was found in the analysis for cancer, accident or suicide. The large number of patients included in this meta-analysis gives the ability to assess sex-specific associations for cause-specific outcomes. This study is limited by absence of standardization for case ascertainment and endpoint definition.

Click to read the study in The Lancet Diabetes and Endocrinology

Relevant Reading: Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study

RELATED REPORTS

Oral semaglutide reduces cardiovascular event rates in high-risk patients

Semaglutide improves walking ability in patients with peripheral artery disease and type 2 diabetes

Diabetic polyneuropathy observed to have dynamic changes overtime

In-Depth [systematic review and meta-analysis]: This study assessed whether or not sex differences exist in mortality outcomes for men and women with type 1 diabetes. PubMed was searched for studies published between Jan. 1, 1966 and Nov. 26, 2014. Overall, 26 studies were included in this meta-analysis, representing 214,114 individuals and 15,273 events. Included studies reported sex-specific estimates of the standardized mortality ratio (SMR) or hazard ratios associated with type 1 diabetes, either for all cause or cause-specific outcomes. Sex-specific SMRs and their pooled ratio (rSMR) (women to men) for all cause mortality, for morality from cardiovascular disease, renal disease, the combined outcomes of accident and suicide, cancer, and from incident coronary heart disease and stroke associated with type 1 diabetes were analyzed.

Overall, the pooled rSMR (women to men) demonstrated a significantly greater excess risk of all-cause mortality in women with type 1 diabetes (rSMR 1.37, [95% CI 1.21–1.56], p<0.0001). Pooled rSMR for fatal renal disease was 1.44 ([1.02–2.05], p=0.0404) and for cardiovascular disease mortality 1.86 ([1.62–2.15], p<0.0001, I.=2.39%). For incident stroke, rSMR suggested increase risk for women at 1.37 (1.03–1.81). In analysis of incident coronary heart disease, the sex difference was more pronounced, with an rSMR of 2.54 (95% CI 1.80–3.60). No evidence of significant difference between women and men was found for cancer, or accident and suicide; rSMR (1.23, [95% CI, 0.79–1.98], p=0.32); rSMR 1.34 (0.97–1.84, p=0.073), respectively.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. No article should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2 Minute Medicine, Inc.

Tags: diabetestype 1 diabetes
Previous Post

Contraception information sheet improves knowledge in dermatology patients

Next Post

IUD, implant may be effective beyond FDA-approved duration

RelatedReports

Mediterranean diet linked to reduced diabetes risk in high risk cardiovascular patients
Cardiology

Oral semaglutide reduces cardiovascular event rates in high-risk patients

June 5, 2025
Increased number of daily steps linked with decreased mortality in older women
Chronic Disease

Semaglutide improves walking ability in patients with peripheral artery disease and type 2 diabetes

May 29, 2025
Chronic Disease

Diabetic polyneuropathy observed to have dynamic changes overtime

May 21, 2025
Food environment associated with gestational diabetes
Pharma

Eli Lilly Takes Legal Action Against Telehealth Startups

May 15, 2025
Next Post

IUD, implant may be effective beyond FDA-approved duration

Reinnervation of cardiac infarcts decreases subsequent arrhythmia incidence [PreClinical]

Reinnervation of cardiac infarcts decreases subsequent arrhythmia incidence [PreClinical]

Combination therapy with tofacitinib improves response in rheumatoid arthritis

Recent intestinal, urological infections linked with lower rheumatoid arthritis risk

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Structured Exercise after Adjuvant Chemotherapy for Colon Cancer
  • 2 Minute Medicine Rewind June 30, 2025
  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.