• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Recent intestinal, urological infections linked with lower rheumatoid arthritis risk

byDaniel FisherandRavi Shah
February 8, 2015
in Chronic Disease, Gastroenterology, Infectious Disease, Urology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Patients who developed rheumatoid arthritis (RA) were less likely to have had a gastrointestinal (GI) or genitourinary (GU) infection within the previous two years.

2. Recent gastroenteritis was linked with a lowere RA risk in patients with both the presence and absence of anti-citrullinated protein antibodies (ACPA).

Evidence Rating Level: 3 (Average)

Study Rundown: A connection between recent infections and the risk of rheumatoid arthritis (RA) has long been hypothesized. In addition, the connection between the microbiome and autoimmunity has been an important area of investigation, especially for RA. This Swedish case-control study, a subset of the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, documented incidence of RA over a 10 year period and collected data about infections within in two years preceding diagnosis. After adjusting for socioeconomic status and smoking, the study found that patients with a recent history of gastroenteritis and urinary tract infection had a lower risk of developing RA than those that did not. While prostatitis also showed a borderline significant reduction in risk, there was no association found with sinusitis, tonsillitis, and pneumonia. When separating the patients into anti-citrullinated protein antibody (ACPA)+, a frequently used biomarker for RA, and ACPA- groups, a decreased risk of RA in patients with previous gastroenteritis history was still found in both groups. However, ACPA+ RA risk was also reduced in patients with urinary tract infections, genital infections, or sinusitis, while there was a borderline significant increase risk of ACPA- RA associated with sinusitis.

The results of this study are intriguing in that they generate evidence to hypothesize that a mechanistic link between the microbiome and RA may exist. Still, the data presented in this study is not without its potential for bias, especially since history of recent infection was self-reported and the exact nature of the reported infections could not be discerned. In addition, an analysis of risk by sex would have been informative, though female patients made up 72% of participants and may have made detecting differences from males more difficult. Overall, the findings warrant a more rigorous study to further parse the relationship between host microbiome, infection, and autoimmunity.

Click to read the study in Annals of the Rheumatic Diseases

Relevant Reading: Microbial infection and rheumatoid arthritis

RELATED REPORTS

Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis

#VisualAbstract: Immune dysfunction is associated with a higher risk of breakthrough COVID-19 infection

#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions

In-Depth [case-control study]: 6401 participants, 72% female and 83% of sampled participants from the EIRA study, were included in this Swedish study from 1996-2009. Patients with RA were given a questionnaire about infection within the previous two years as were control patients that were age, sex, and residence area matched, selected by incidence density sampling randomly. For the entire sample, recent gastroenteritis (OR = 0.71 CI95% 0.63-0.80), urinary tract infection (OR = 0.78 CI95% 0.68-0.90), and prostatitis (OR = 0.80 CI95% 0.64-1.00) were associated with lower risk of RA. No association was found for sinusitis, tonsillitis, and pneumonia. Further, ACPA+ patients had a decreased risk of RA with a previous history of gastroenteritis, urinary tract infection, genital infection, and sinusitis, while ACPA- patients only had reduced risk with gastroenteritis and an increased risk of RA with sinusitis. No significant differences in RA risk were detectable by very recent infections versus infection from 1-2 years ago, smoking, sex, socioeconomic status, and epitope status.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. No article should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2 Minute Medicine, Inc.

Tags: rheumatoid arthritis
Previous Post

Reinnervation of cardiac infarcts decreases subsequent arrhythmia incidence [PreClinical]

Next Post

Diet, exercise may improve endothelial function in obese teens

RelatedReports

2 Minute Medicine Rewind January 28, 2019
Cardiology

Tofacitinib increases cardiovascular and cancer risk in rheumatoid arthritis

February 2, 2022
#VisualAbstract: Immune dysfunction is associated with a higher risk of breakthrough COVID-19 infection
StudyGraphics

#VisualAbstract: Immune dysfunction is associated with a higher risk of breakthrough COVID-19 infection

January 5, 2022
#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions
Chronic Disease

#VisualAbstract Granuloma annulare was associated with increased risk of type 2 diabetes, hyperlipidemia, and certain autoimmune conditions

June 18, 2021
2 Minute Medicine Rewind January 28, 2019
Chronic Disease

Cardiovascular safety of hydroxychloroquine in veterans with rheumatoid arthritis

May 20, 2021
Next Post
Diet, exercise may improve endothelial function in obese teens

Diet, exercise may improve endothelial function in obese teens

Noninvasive ventilation strategies examined in NICU infants

Noninvasive ventilation strategies examined in NICU infants

Retinopathy of prematurity associated with nonvisual impairment in childhood

2 Minute Medicine Rewind February 1 – February 8, 2015

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.