• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Significant decline in mortality related to diabetes from 1998 to 2014

byAndrew Cheung, MD MBAandMatthew Growdon
April 13, 2017
in Chronic Disease, Endocrinology, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a large Swedish registry-cohort study, the authors report significant declines in all-cause mortality and diabetes-related complications in patients with both type 1 and 2 diabetes.

2. There was a similar decline in all-cause mortality between patients with type 1 diabetes and controls, whereas a greater decline in fatal outcomes was observed in controls compared to those with type 2 diabetes.

Evidence Rating Level: 2 (Good)

Study Rundown: In recent decades, improved understanding of type 1 and 2 diabetes has led to the adoption of evidence-based strategies for the prevention and treatment of diabetes as a form of cardiovascular risk reduction. Drawing on the Swedish National Diabetes Register, the study authors sought to investigate long-term trends in all-cause mortality and diabetes-related complications among diabetic patients versus non-diabetic matched controls in the Swedish population from 1998 to 2014. The authors report a significant decline in all-cause mortality and diabetes-related complications in patients with both type 1 and 2 diabetes. There was a similar decline in all-cause mortality between patients with type 1 diabetes and controls, whereas a greater decline in fatal outcomes was observed in controls compared to those with type 2 diabetes. In terms of nonfatal outcomes, including hospitalizations for myocardial infarction, coronary heart disease, and stroke, there were significant decreases in both diabetes groups compared to matched controls. Across all outcomes, there was a much higher rate of adverse outcomes, in absolute terms, in the diabetic groups compared to controls.

This study leverages the powerful Swedish diabetes registry in a matched-cohort design to show substantial improvements in mortality and cardiovascular complications among type 1 and 2 diabetic patients. Interestingly, they report a decline in heart failure related complications among patients with type 2 diabetics compared to controls, but not among type 1 diabetic patients. As with all registry studies, potential limitations include the possibility of misclassification bias and unaccounted secular trends.

Click to read the study, published today in NEJM

Relevant Reading: Projection of the year 2050 burden of diabetes in the US adult population

RELATED REPORTS

Low-carbohydrate, high-fat diet improves glycemic control in type 2 diabetic patients

Meta-analysis shows significant decrease in age-related macular degeneration risk with metformin use

SGLT2 inhibitors reduce the risk of kidney disease in patients with and without diabetes

In-Depth [retrospective cohort]: This study involved 36 869 patients with type 1 diabetes and 457 473 patients with type 2 diabetes drawn from the Swedish National Diabetes Register, matched (by age, sex, and county) with controls from the general Swedish population. Patients with type 1 diabetes were on average 35 years of age; those with type 2 diabetes were on average 65.2 years of age at study entry. There was a median of 15 years of observation in the cohort. In terms of all-cause mortality, the absolute changes were -31.4 and -69.6 deaths per 10,000 person-years in the type 1 and type 2 diabetes cohorts, respectively. The hazard ratio comparing all-cause mortality in patients with type 1 diabetes compared to controls was 1.08 (95%CI 0.99 to 1.18; p = 0.09). The corresponding hazard ratio for controls compared to patients with type 2 diabetes was 0.87 (95%CI 0.85 to 0.89; p < 0.001). In terms of hospitalization for cardiovascular disease, there were event rate reductions of 36% and 44% among patients with type 1 and 2 diabetes, respectively; these rates were significantly higher than those found among matched controls, a finding that was consistent for hospitalizations related to myocardial infarction, coronary heart disease, and stroke. There was no significant difference in the rate of hospitalization for heart failure in patients with type 1 diabetes compared to controls; there was a 29% reduction in hospitalization for heart failure in patients with type 2 diabetes compared to controls (HR 0.71; 95%CI 0.69 to 0.73).

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: diabetes mellitus
Previous Post

Higher incidence of stroke and greater prevalence of stroke risk factors in younger adults over the last decade

Next Post

2 Minute Medicine Rewind April 10, 2017

RelatedReports

Pediatric DKA associated with recent acute care visits
Cardiology

Low-carbohydrate, high-fat diet improves glycemic control in type 2 diabetic patients

January 11, 2023
Antioxidants, omega-3 lack benefit in age-related macular degeneration
Ophthalmology

Meta-analysis shows significant decrease in age-related macular degeneration risk with metformin use

December 19, 2022
Tenofovir disoprovil fumarate HIV prophylaxis linked with minimal kidney impact
Chronic Disease

SGLT2 inhibitors reduce the risk of kidney disease in patients with and without diabetes

November 30, 2022
Parental debt influences child socioemotional well-being
Chronic Disease

Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists improve diabetes outcomes but are not cost effective

October 20, 2022
Next Post
Adding daratumumab increases progression free survival in multiple myeloma

2 Minute Medicine Rewind April 10, 2017

Epidural corticosteroid injections provide only short-term radiculopathy pain relief

Spinal manipulative therapy linked to modest improvements in pain and function for acute low back pain

Epileptogenic foci may be lateralized using functional brain glutamate imaging

Midlife vascular risk factors linked with higher brain amyloid in later life

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
  • Homicide deaths are on the rise for children living in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options