• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home Wellness

Spectrophotometric assays for methadone may be effective for diversion control

byNancy LuandAvneesh Bhangu
April 26, 2022
in Wellness
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Methadone is a regulated medication that is effective in treating opioid use disorder; however, diversion of take-home methadone can occur and is difficult to detect.

2. One method of detection may be to utilize a handheld spectrophotometric assay to detect doses of methadone that may have been altered by the patient.

Evidence Rating Level: 2 (Good)

Opioid use disorder is a condition which may be treated with a variety of medications, including methadone. However, there is a risk of diversion, defined as patients selling or giving away their methadone to others. Methadone has a narrow margin of safety and the potential for dangerous results such as overdose on diverted methadone exists. The purpose of this study was to determine whether a low-cost ultraviolet (UV) light spectrometer could be used to determine if methadone doses were altered at home, which could potentially detect instances of diversion.

This study used methadone liquid concentrate obtained by several suppliers, with the largest being Roxane Laboratories (Columbus, Ohio, United States), with the study being conducted in South Burlington, Vermont, United States. 10 methadone doses were prepared as controls to determine confidence intervals. These doses were compared to 104 random bottles obtained over a 10 month period, followed by an additional 103 bottles with concern for diversion from 27 patients collected over an additional 14 month period. UV-visible spectrophotometry was then performed on these samples, and methadone concentrations were recorded.

The results demonstrated that spectrophotometry may be a viable method to determine whether diversion had occurred. Out of the bottles with concern for diversion, 15 had <25% and 8 had <75% of the expected concentration. However, this study did note limitations of the spectrophotometry assay, such as the expense of the instrumentation, and the requirement for clinical staff to become acquainted with performing the intrinsic steps necessary for operation of the instrumentation. Despite these limitations, this pilot study suggests that spectrophotometry may be an easy, low-cost way of determining some instances of methadone diversion.

Click to read the study in Journal of Addiction Medicine 

RELATED REPORTS

Medical cannabis provides little improvement to sleep in chronic pain patients

Gratitude-focused writing may improve mental wellness during periods of chronic stress

University students perceive that Instagram improves social connection but impairs mental wellbeing

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: addictionsdiversionmethadoneopioidopioid use disorderwellness
Previous Post

Comparison of mastectomy and breast reconstruction versus conservative surgery with radiation

Next Post

#VisualAbstract: Ruxolitinib use may be associated with higher incidences of nonmelanoma skin cancers

RelatedReports

Parental cannabis use increasing, cigarette use decreasing
Chronic Disease

Medical cannabis provides little improvement to sleep in chronic pain patients

May 27, 2022
Quick Take: Effect of Developmentally Adapted Cognitive Processing Therapy for Youth With Symptoms of Posttraumatic Stress Disorder After Childhood Sexual and Physical Abuse
Psychiatry

Gratitude-focused writing may improve mental wellness during periods of chronic stress

May 24, 2022
2 Minute Medicine Rewind October 21, 2019
Wellness

University students perceive that Instagram improves social connection but impairs mental wellbeing

May 23, 2022
Exercise intervention linked to reduced functional decline among elderly patients admitted to the hospital
Wellness

Virtual yoga and meditation intervention may be associated with increased health-related quality of life

May 20, 2022
Next Post
#VisualAbstract: Ruxolitinib use may be associated with higher incidences of nonmelanoma skin cancers

#VisualAbstract: Ruxolitinib use may be associated with higher incidences of nonmelanoma skin cancers

Being overweight and obese associated with increased incidence of chronic kidney disease

Oral tacrolimus noninferior to intravenous cyclophosphamide for lupus nephritis

#VisualAbstract: Fewer hospital admissions and death were seen with SARS-CoV-2 Delta (B.1.617.2) compared to Omicron (B.1.1.529) variant infections

#VisualAbstract: Fewer hospital admissions and death were seen with SARS-CoV-2 Delta (B.1.617.2) compared to Omicron (B.1.1.529) variant infections

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.