Tag: angioedema

1. In patients with reported history of penicillin allergy, a clinical prediction tool based on timing, character, and severity of the reaction accurately predicted results of further confirmatory allergy testing. 2. Using a score cut-off of 3 points, the PEN-FAST prediction tool had a high negative predictive probability in ruling...
1. In this randomized controlled trial, prophylactic lanadelumab reduced attack frequency and severity in patients with hereditary angioedema compared to placebo. 2. The most common adverse reactions associated with lanadelumab treatment were injection site reactions and headache. Evidence Rating Level: 1 (Excellent)    Study Rundown: Hereditary angioedema is an autosomal dominant disorder caused...
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder characterized by C1 inhibitor deficiency (type I) or dysfunction (type II) causing dysregulated plasma kallikrein activity, and in turn, life-threatening recurrent angioedema...
1. The self-administered, subcutaneous C1-inhibitor CSL830 demonstrated a dose-dependent high efficacy in the prophylactic treatment of hereditary angioedema (HAE) attacks compared to placebo. 2. CSL830 was well-tolerated and not associated with significant adverse events. Evidence Rating Level: 1 (Excellent)  HAE is a rare genetic disorder resulting from a deficiency (type 1)...