Tag: Antidepressant

1. Amongst patients with moderate to severe depression being initiated on pharmacotherapy, using the shared decision-making tool, Depression Medication Choice, made patients and physicians feel greater comfort and empowerment compared to usual care. 2. However, the Depression Medication Choice had no significant effect on patient adherence or depression outcomes at...
1. Women exposed to antidepressants in late gestation were at greater risk of postpartum hemorrhage than unexposed controls. 2. No increased risk was seen for women with psychiatric illness but no antidepressant use. Evidence Rating Level: 2 (Good) Study Rundown: Worldwide, the number of women on antidepressants in pregnancy has increased dramatically...
1. In this retrospective cohort study of Danish mothers and children, maternal use of newer antidepressants (e.g. SSRIs, nefazodone, mirtazapine, venlafaxine, and roboxetine) during pregnancy was not associated with an increased risk of childhood asthma. 2. Maternal prenatal use of older antidepressants (e.g. tricyclic antidepressants) was associated with an approximately...
1. The use of antidepressants during the first trimester of pregnancy was not significantly associated with higher risk of congenital cardiac abnormalities in this large, population-based cohort study. 2. The use of paroxetine and sertraline during the first trimester were not significantly linked with higher risk of right ventricular outflow...
Image: PD  1.  In patients younger than 24 years of age, higher doses of antidepressants doubled the risk of deliberate self-harm.  2.  In adults, there was no significant increase in the risk of deliberate self-harm with the use of higher dose anti-depressants.  Evidence Rating Level: 2 (Good) Study Rundown:  A meta-analysis published in...
Image: PD 1. Mothers’ prenatal selective serotonin reuptake inhibitor (SSRI) use was linked to an increased risk of autism spectrum disorder (ASD) in male children. 2. The risk of ASD was highest among those mothers who used SSRIs in the first trimester.  Evidence Rating Level: 3 (Average) Study Rundown: SSRIs can cross the...
Image: PD 1. When compared to fluoxetine, a selective serotonin reuptake inhibitor (SSRI) and the current FDA-recommended antidepressant for children with major depressive disorder, no significant difference in risk of medically treated suicide attempts was observed between those treated with other SSRI antidepressants and serotonin-norepinephrine reuptake inhibitors (SNRIs). 2. A significant,...
Image: PD 1. Rates of mental stress-induced myocardial ischemia (MSIMI) were significantly lower in patients taking escitalopram (Lexapro) vs. placebo at the end of 6 weeks. 2. Rates of exercise-induced myocardial ischemia (ESIMI) were not significantly reduced in patients taking escitalopram vs. placebo at the end of 6 weeks. Evidence Rating Level:...