Tag: appendicitis

Patients presenting with appendicitis are typically stratified as having either uncomplicated or complicated acute appendicitis, the latter of which may include the formation of a closed, circumscribed periappendicular abscess. While early appendectomy in the acute phase is the standard of care in the adult patient population, there is evidence...
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder characterized by C1 inhibitor deficiency (type I) or dysfunction (type II) causing dysregulated plasma kallikrein activity, and in turn, life-threatening recurrent angioedema...
1. Time from initial emergency department evaluation to appendectomy onset was not associated with increased odds of appendiceal perforation (AP). 2. Increased perforation risk was most significantly associated with longer duration of time from onset of abdominal pain and presentation to the emergency department. Study Rundown: Diagnosing appendicitis is particularly challenging...
1. In a prospective study of over 570 children with appendicitis, ultrasound (US) is highly specific but not sensitive in the detection of appendix perforation. 2. Duration of symptoms, greater maximum diameter, simple and complex peri-appendiceal fluid, and the presence of an appendicolith was positively associated with appendix perforation. Evidence Rating...
1. In a retrospective review of over 96 000 children with acute appendicitis, there was a significant decrease in the utilization of computed tomography (CT) and a corresponding increase in ultrasound from 2005 to 2014. 2. Imaging costs for appendicitis have remained relatively constant over this period, while the proportion...
  1. In a prospective trial of 168 patients with suspected acute appendicitis (AA), patients that underwent external compression (EC) computed tomography (CT) demonstrated higher specificity for the diagnosis of acute appendicitis compared to standard CT scan. Evidence Rating Level: 2 (Good)            Study Rundown: In patients with suspected AA, imaging with ultrasound...
1. In patients with suspected appendicitis and equivocal ultrasound results, a low clinical score such as the Alvarado or Pediatric Appendicitis score was helpful in identifying patients with a low likelihood of disease. 2. Only slightly more than one-tenth of ultrasound examinations for appendicitis produced equivocal results, which could be...
1. In young patients with right lower quadrant (RLQ) pain who present to the emergency department, abdominal magnetic resonance imaging (MRI) performed without intravenous or oral contrast enhancement detected acute appendicitis with a high sensitivity and specificity based upon reference surgical results and clinical follow-up data. 2. In patients who...
1. In patients with suspected acute appendicitis, baseline computed tomography (CT) studies identified predictors of surgical management, same-day discharge and repeat imaging or representation within 30 days, thereby secondarily predicting the costs of associated hospitalization and resource use. 2. Findings on CT showed that small appendiceal diameter, absence of periappendiceal...
1. For CT-proven, uncomplicated appendicitis, antibiotic treatment was not shown to be non-inferior compared to appendectomy. 2. Most patients randomized to antibiotic treatment did not require an appendectomy in the 1-year follow-up period. Those who did require appendectomy during that time period did not experience significant complications. Evidence Rating Level: 1...