Tag: atrial fibrillation

1. Significant variation in benefit per person was observed depending on stroke rates utilized in current guidelines. 2. The greatest population benefit was shown when using stroke rates from the Danish National Patient Registry. Evidence Rating Level: 2 (Good) Study Rundown: Patients with atrial fibrillation (AF) are often treated with oral anticoagulation,...
1. In this randomized controlled trial, patients who received immediate atrial fibrillation (AF) monitoring with a new, wearable EKG were more likely to have their AF diagnosed compared to the delayed monitoring group. 2.Participants in the active monitoring group had a higher rate of initiation of anticoagulant therapy specifically for...
1. In this meta-analysis, addition of vasopressin to catecholamine vasopressors was associated with a lower risk of atrial fibrillation when compared to catecholamine monotherapy. 2. While there was decreased mortality with vasopressin plus catecholamines, this difference was not seen when restricting analysis to studies with a low risk of bias. Evidence...
1. Compared to medical therapy alone, catheter ablation of atrial fibrillation in patients with heart failure reduced the risk of all-cause mortality and hospitalization. 2. Procedural complications of catheter ablation included pericardial effusion and severe bleeding. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation is a common comorbidity that worsens outcomes...
1. Cluster analysis of a population of patients with atrial fibrillation (AF) identified four unique phenotypes using variables not traditionally associated with AF classification. 2. The four phenotypic AF groups were associated with differences in treatment strategies and clinical outcomes. Evidence Rating Level: 3 (Average)     Study Rundown: Atrial fibrillation is the most...
1. The analysis of data from more than 50,000 patients showed that both dabigatran and warfarin were associated with similar amounts of bleeding and rates of ischemic stroke. 2. Dabigatran is a safe alternative to warfarin for reducing the risk of stroke in patients with atrial fibrillation. Evidence Rating Level: 2...
Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation Patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) typically receive warfarin and two antiplatelet drugs as part of the current standard of care. However, studies have shown that this approach is associated with an increased risk of major bleeding....
Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension  Early resuscitation protocols have been shown to reduce sepsis mortality. However, studies have been primarily conducted in high-income, high-resource countries, with little research in low- and middle-income countries. In this randomized controlled trial, 212 adults...
1. In this randomized controlled trial, rivaroxaban and warfarin were similar in safety and efficacy when used to prevent early recurrence of stroke in patients with atrial fibrillation (AF)-related acute ischemic stroke. 2. Rivaroxaban was associated with reduced hospital length of stay. Evidence Rating Level: 2 (Good) Study Rundown: Patients that have...
  Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMEN): an international, randomised, double-blind, placebo-controlled trial The leading cause of maternal death worldwide is post-partum hemorrhage. Tranexamic acid reduces blood loss by inhibiting plasmin in the breakdown of fibrinogen and fibrin, and...