Tag: biomarkers

1. Serum IL-6 and TNF-α were strong, independent predictors of disease severity and death among those with suspected and confirmed SARS-CoV-2 infection. Evidence Rating Level: 2 (Good) Hyperinflammatory responses, or cytokine storms, are known results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), serving as a basis for disease severity and...
1. In a study of children with community acquired pneumonia, initial biomarker levels (C-reactive protein, white blood cell count, procalcitonin, absolute neutrophil count) were similar across illness severities. 2. Higher C-reactive protein and procalcitonin levels were predictive of specific severe outcomes, including empyema requiring chest drainage and septic shock. Evidence Rating...
Multiple myeloma often develops from the precursor condition monoclonal gammopathy of undetermined significance (MGUS), which is detectable in peripheral blood. Similarly, the light-chain subtype of multiple myeloma is preceded by light-chain MGUS. Clinical guidelines recommend annual peripheral blood monitoring of serum immune markers for patients with intermediate-risk and high-risk...
Human prion disease, also known as Creutzfeldt-Jakob disease (CJD), is a neurodegenerative disease caused by abnormally folded prion proteins. The progression of CJD is rapid, with time from diagnosis to death being approximately 4 to 6 months. Currently, there is a need to more accurately predict disease duration in...
Amyotrophic Lateral Sclerosis versus Multifocal Motor Neuropathy: Utility of MR Neurography Both multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) affect the peripheral nervous system and present with palsies. Differentiating between these two diseases is important from a prognostic perspective, as MMN should be treated as early as possible...
Alzheimer disease (AD) is characterized by the accumulation of amyloid b (Ab) and tau aggregates in the brain. The progression of AD can be monitored through imaging techniques or through the use of cerebrospinal fluid (CSF) biomarkers. As these modalities are expensive and invasive, an alternative method is needed....
Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease Alzheimer disease (AD) is characterized by the accumulation of amyloid b (Ab) and tau aggregates in the brain. The progression of AD can be monitored through imaging techniques or through the use of cerebrospinal fluid (CSF) biomarkers....
Tuberculosis (TB) is the leading cause of death by an infectious disease. Identifying affected individuals, particularly if they are asymptomatic, however, remains a challenge as the infectious organisms are primarily contained within lung granulomas and/or draining lymph nodes. Biomarkers in the host’s blood compartment may be used in identifying...
Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis Fetal presentation has long been determined by way of clinical examination only, despite the relative ease with which breech presentation can be identified through ultrasound screening. As such, many women continue to present in...