Tag: Cardiomyopathy
1. Compared to placebo, patients treated with mavacamten for 30 weeks showed significant improvements on the KCC Questionnaire which evaluates health status and quality of life.
2. In patients with symptomatic hypertrophic cardiomyopathy, the number needed to treat with mavacamten was 5.
Evidence Rating Level: 2 (Good)
Study Rundown: The EXPLORER-HCM...
1. In this study of White and African American adults who had unexplained sudden cardiac death, nearly 20% of individuals had pathogenic or likely pathogenic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings.
2. These findings suggest that genetic testing could play a greater role...
1. Among post-myocardial infarction patients with left ventricular dysfunction, an infusion of cardiosphere-derived cells did not significantly reduce scar size at six months.
2. Favorable changes among the infusion cohort, however, were noted in markers of left ventricular remodeling and heart failure.
Evidence Level Rating: 1 (Excellent)
Cardiovascular disease is responsible for...
With the large and growing population of cancer survivors over the last several decades, there exists significant concern that these patients may be at an increased risk of cardiovascular disease. However, few studies have examined risks of multiple specific outcomes of cardiovascular disease in survivors of a wide range...
1. Patients with ICD therapy had an overall reduction in all-cause mortality compared to conventional care.
2. The rate of sudden death was decreased in ICD patients.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Implantable cardioverter defibrillators (ICD) are currently used to prevent sudden death in patients with ventricular arrhythmias. Studies have...
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
The cause of peripartum cardiomyopathy remains unknown and it has been hypothesized in the literature that it may have a significant genetic component. It shares many clinical similarities to idiopathic dilated cardiomyopathy. Using this association, the authors of this paper sequenced 43...