Tag: Cardiomyopathy

1. Among post-myocardial infarction patients with left ventricular dysfunction, an infusion of cardiosphere-derived cells did not significantly reduce scar size at six months. 2. Favorable changes among the infusion cohort, however, were noted in markers of left ventricular remodeling and heart failure. Evidence Level Rating: 1 (Excellent) Cardiovascular disease is responsible for...
With the large and growing population of cancer survivors over the last several decades, there exists significant concern that these patients may be at an increased risk of cardiovascular disease. However, few studies have examined risks of multiple specific outcomes of cardiovascular disease in survivors of a wide range...
1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos. 2. No off-target effects were detected. Evidence Rating Level: 1 (Excellent) Study Rundown: A dominant mutation in the gene MYBPC3 causes hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in otherwise...
1. Patients with ICD therapy had an overall reduction in all-cause mortality compared to conventional care. 2. The rate of sudden death was decreased in ICD patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Implantable cardioverter defibrillators (ICD) are currently used to prevent sudden death in patients with ventricular arrhythmias. Studies have...
  Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies The cause of peripartum cardiomyopathy remains unknown and it has been hypothesized in the literature that it may have a significant genetic component. It shares many clinical similarities to idiopathic dilated cardiomyopathy. Using this association, the authors of this paper sequenced 43...

Patient Basics: Cardiomyopathy

Originally published by Harvard Health. What Is It? Cardiomyopathy refers to changes in the heart muscle. These changes prevent part or all of the heart from contracting normally. There are three types of cardiomyopathy. The types are based on the physical changes that occur in the heart: Dilated cardiomyopathy — The damaged heart...