Tag: CD4

1.  Chemotherapy and/or radiotherapy may provoke significant declines in CD4 counts in HIV patients as compared to other treatments, which in turn are associated with increased mortality. Evidence Rating Level: 2 (Good) Treating cancer in patients with human immunodeficiency virus (HIV) infection can be problematic due to the immunosuppressive effects of certain...
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial 1. Obeticholic acid, a farnesoid X receptor agonist, prompts fibrosis improvement in patients with non-alcoholic steatohepatitis (NASH) Evidence Rating Level: 1 (Excellent) Non-alcoholic steatohepatitis (NASH) is an increasingly common cause of chronic liver disease...
Image: PD 1. Transfer of autologous CD4 T cells, with genome editing of the CCR5 gene, to HIV patients was successful and safe 2. Levels of modified CD4 T cells declined at a lower rate than unmodified CD4 T cells when antiretroviral therapy was interrupted Evidence Rating Level:  2 (Good) Study Rundown:...
Image: PD 1. HIV-1 transmission rates were significantly lower in the early-therapy group compared to the delayed-therapy group 2. Patients in the early-therapy group had lower incidence of HIV-related clinical events with a lower viral load and higher CD4 cell count than those whose therapy was delayed Original Date of Publication: August...