Tag: cirrhosis

1. In this retrospective cohort study of Medicare patients, history of liver cirrhosis was associated with increased risk of stroke compared with patients without cirrhosis. 2. Patients with cirrhosis had a greater magnitude of risk for hemorrhagic compared to ischemic strokes. Evidence Rating Level: 2 (Good)        Study Rundown: Liver cirrhosis and cerebrovascular...
1. Obeticholic acid therapy in patients with primary biliary cholangitis (PBC) associated with significantly greater decreases in alkaline phosphatase (ALP) and total bilirubin over 12 month period compared to placebo. 2. Higher rates of pruritis and subsequent discontinuation in patients treated with obeticholic acid compared to placebo.  Evidence Rating Level: 1...
1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved or possible infections when compared to those treated with norfloxacin. 2. The ceftriaxone group was also significantly less likely to developed proved infections or spontaneous bacteremia and bacterial peritonitis. 3. There...
1. Medical decision making in patients with hepatitis C (HCV) may be aided by knowing the likely rate of liver fibrosis. 2. Seroconversion for HCV increased the rate of liver fibrosis and hastened eventual development of cirrhosis. Evidence Rating Level: 3 (Average)      Study Rundown: This study sought to better characterize...

Patient Basics: Cirrhosis

Originally published by Harvard Health. What Is It? No body organ performs a wider variety of essential jobs than the liver. It: Produces essential proteins that help blood to clot Removes or neutralizes poisons, drugs and alcohol Manufactures bile that helps the body to absorb fats and cholesterol Helps to maintain normal blood sugar levels Regulates...
Classics Series, Landmark Trials in Medicine
1. In cirrhotic patients with spontaneous bacterial peritonitis, albumin infusion on days 1 and 3 of treatment in addition to antibiotics significantly reduces the risk of developing renal impairment and mortality when compared with antibiotics alone. Original Date of Publication: August 5, 1999 Study Rundown: Renal impairment during spontaneous bacterial peritonitis...
1. More patients treated with polyethylene glycol had improvement in their hepatic encephalopathy scoring algorithm (HESA) score, as compared to patients treated with lactulose. 2. Patients receiving polyethylene glycol had larger mean improvement of the HESA score and had faster resolution of symptoms, as compared to those receiving lactulose. Evidence Rating...
Image: PD 1. In patients with severe liver disease and variceal bleeding, early transjugular intrahepatic portosystemic shunt (TIPS) significantly reduced the rate of treatment failure, length of hospitalization, and mortality 2. Early TIPS was not associated with a difference in the rate of adverse events compared to control Original Date of Publication:...
1. The Child-Pugh score consists of five clinical features and is used to assess the prognosis of chronic liver disease and cirrhosis. 2. The Child-Pugh score was originally developed in 1973 to predict surgical outcomes in patients presenting with bleeding esophageal varices. 3. The score is used with the Model for...
Classics Series, Landmark Trials in Medicine
Image: PD 1. The Model for End-Stage Liver Disease (MELD) is a reliable tool for predicting short-term survival in patients with advanced liver disease 2. The score is generalizable to diverse etiologies and a wide range of disease severity Original Date of Publication: February 2001 Study Rundown: The Model for End-Stage Liver Disease (MELD)...