Tag: cirrhosis

1. In a cohort of patients with alcoholic liver disease, adherence to a 6-month abstinence period prior to liver transplant was not associated with improved post-surgical outcomes. Evidence Rating Level: 2 (Good) Although alcohol-associated liver disease is a leading indication for liver transplant, patients are often denied access due to pre-transplantation...

1. Administration of human albumin solution was shown not to lead to any clinical improvement in patients hospitalized with cirrhosis. 2. The albumin group had more serious adverse events such as pulmonary edema or fluid overload compared to the standard of care group. Evidence Rating Level: 1 (Excellent) Study Rundown: Liver cirrhosis is one...

1. In this retrospective cohort study of Medicare patients, history of liver cirrhosis was associated with increased risk of stroke compared with patients without cirrhosis. 2. Patients with cirrhosis had a greater magnitude of risk for hemorrhagic compared to ischemic strokes. Evidence Rating Level: 2 (Good)        Study Rundown: Liver cirrhosis and cerebrovascular...

1. Obeticholic acid therapy in patients with primary biliary cholangitis (PBC) associated with significantly greater decreases in alkaline phosphatase (ALP) and total bilirubin over 12 month period compared to placebo. 2. Higher rates of pruritis and subsequent discontinuation in patients treated with obeticholic acid compared to placebo.  Evidence Rating Level: 1...

1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved or possible infections when compared to those treated with norfloxacin. 2. The ceftriaxone group was also significantly less likely to developed proved infections or spontaneous bacteremia and bacterial peritonitis. 3. There...

1. Medical decision making in patients with hepatitis C (HCV) may be aided by knowing the likely rate of liver fibrosis. 2. Seroconversion for HCV increased the rate of liver fibrosis and hastened eventual development of cirrhosis. Evidence Rating Level: 3 (Average)      Study Rundown: This study sought to better characterize...

1. In cirrhotic patients with spontaneous bacterial peritonitis, albumin infusion on days 1 and 3 of treatment in addition to antibiotics significantly reduces the risk of developing renal impairment and mortality when compared with antibiotics alone. Original Date of Publication: August 5, 1999 Study Rundown: Renal impairment during spontaneous bacterial peritonitis...

1. More patients treated with polyethylene glycol had improvement in their hepatic encephalopathy scoring algorithm (HESA) score, as compared to patients treated with lactulose. 2. Patients receiving polyethylene glycol had larger mean improvement of the HESA score and had faster resolution of symptoms, as compared to those receiving lactulose. Evidence Rating...