Tag: Clinical trials

1. 35% of reanalyzed clinical trials demonstrated conclusions that differed from the conclusions reached by the original article. 2. No statistically significant association was noted between changes in article conclusions following reanalysis and the use of independent versus original study authors. Evidence Rating Level: 2 (Good)            Study Rundown:...
Image: PD  1. Poor participant recruitment was found to be the most common cause of randomized controlled trial (RCT) discontinuation. 2. Factors associated with not publishing results of RCTs include small target sample size, single center design, industry sponsorship, RCT discontinuation, and studies of healthy volunteers as opposed to patients. Evidence Rating...
Image: PD 1. Regular exercise reported at baseline was associated with less pain in repeated measures over a subsequent 12 month period, though this association was attenuated when adjusting for baseline level of pain. 2. Exercise was associated with a significant reduction in concurrent pain, though this association did not persist...
Image: PD 1. Plastic bags made from polyethylene reduced hypothermia among premature and low birth weight newborns by 26%.  2. The use of plastic bags for hypothermia prevention was not associated with hyperthermia or skin side effects. Evidence Rating Level: 1 (Excellent)  Study Rundown: Neonatal hypothermia has been associated with serious adverse outcomes,...
Image: PD 1. Short-term zinc prophylaxis in infants is associated with decreased morbidity from diarrheal episodes.  2. In those infants receiving zinc supplementation, there was a decrease in incidence and duration of diarrheal episodes, and total number of days suffering from diarrhea during the 5 months following supplementation.  Evidence Rating Level:...
Image: PD 1. Moderate evidence exists to suggest that treatment of gestational diabetes (GDM) is associated with a lower likelihood of preeclampsia, shoulder dystocia, and macrosomia. Little evidence exists to suggest an association of GDM treatment with short-term harm. 2. Evidence was insufficient for the association of treatment with numerous outcomes, including long-term...
Image: PD 1. Different c-section techniques  (blunt vs. sharp entry, single-layer vs. double-layer closure, etc.) resulted in equivalent risk for short-term maternal and infant morbidity. 2. Compared to using polyglactin-910 (PG-910) sutures, the use of chromic catgut sutures for uterine repair was associated with lower likelihood of requiring >1 unit of...
Image: PD 1. Rates of mental stress-induced myocardial ischemia (MSIMI) were significantly lower in patients taking escitalopram (Lexapro) vs. placebo at the end of 6 weeks. 2. Rates of exercise-induced myocardial ischemia (ESIMI) were not significantly reduced in patients taking escitalopram vs. placebo at the end of 6 weeks. Evidence Rating Level:...
 Image: PD 1. Service members who had multiple traumatic brain injuries (TBIs) were at greater suicide risk than those who had zero or one TBI. 2.  Among service members with multiple TBIs, there was a positive relationship between depression severity and suicide risk. Evidence Rating Level: 3 (Fair) Study Rundown: This study found...