Tag: corticosteroid

1. Time to recovery was lower in patients assigned to budesonide compared to usual care, meeting the superiority criteria. 2. Rate of hospitalizations or death was numerically lower in the inhaled budesonide group compared to usual care.  Evidence Rating Level: 1 (Excellent) Study Rundown: Systemic corticosteroids, such as dexamethasone, have been widely...
1. There were no significant differences in shoulder pain and disability indices between progressive exercise vs. best practice physiotherapy and corticosteroid injection vs. no injection. 2. Best practice advice (single physiotherapy session) plus corticosteroid injection was found to be the most cost-effective intervention at approximately £479 per quality-adjusted life years...
1. In patients with mild asthma, use of the inhaled combined corticosteroid (ICS) and beta agonist budesonide-formoterol as needed was superior to terbutaline as needed with respect to electronically recorded weeks of well-controlled asthma. 2. While budesonide-formoterol as needed was inferior to twice daily budesonide maintenance therapy with respect to...
1. In this meta-analysis of available comparative studies, use of corticosteroids as adjunctive therapy to IVIG and aspirin in Kawasaki disease was associated with a lower risk of coronary artery abnormality and earlier defervescence compared to IVIG/ASA alone. 2. In subgroup analysis the earlier timing of steroid therapy had lower...
Classics Series, Landmark Trials in Medicine
1. Compared to placebo, treating patients with severe alcoholic hepatitis with 28 days of prednisolone significantly improved the short-term survival up to 6 months. 2. There remains significant controversy surrounding the use of glucocorticoids in managing severe alcoholic hepatitis, as numerous other trials have demonstrated no mortality benefit, but significantly...
1. Use of acute corticosteroids versus placebo in patients with severe community-acquired pneumonia (CAP) and a high initial inflammatory response resulted in a decrease in treatment failure. 2. There was no statistically significant difference in in-hospital mortality between the two groups. Evidence Rating Level: 1 (Excellent) Study Rundown: The mortality of patients...