Tag: epilepsy

1. Antiepileptic drug exposure in infants of breastfeeding mothers being treated for epilepsy is low. Evidence Rating Level: 2 (Good) While breastfeeding for the first 6 months of life is currently recommended by the American Academy of Pediatrics, no consensus exists for the safety of breastfeeding when the mother is receiving antiepileptic...
1. Expert review of smartphone videos possesses additive, predictive value for the diagnosis of epileptic seizures, with the ability to maintain confidentiality in the sharing of these files. Evidence Rating Level: 2 (Good) Video electroencephalogram (EEG) monitoring (VEM) is the ideal diagnostic standard for epileptic seizures when diagnosis is unclear through medical...
Electronic Cigarette and JUUL Use Among Adolescents and Young Adults 1. The use of electronic cigarettes is highly prevalent among adolescents and young adults through the advent of JUUL, which has unique implications for this young and susceptible age group. Evidence Rating Level: 1 (Excellent) Adverse effects of nicotine on overall health,...
Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo: A Secondary Analysis of a Randomized Clinical Trial 1. Immune-related adverse events are associated with a longer recurrence-free survival in patients with stage III melanoma treated with pembrolizumab. Evidence Rating Level:...
1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons. 2. Treatment of rats with a lentiviral plasmid encoding a glutamate-gated chloride channel was able to decrease focal seizure activity by hyperpolarizing neurons and decreasing their effective membrane resistance. Evidence Rating Level: 2...
1. Amongst adults and children with the Lennox-Gastaut (LG) syndrome, addition of cannabidiol to a conventional antiepileptic regimen reduced drop seizure frequency compared to placebo treated patients. 2. The most common adverse events amongst patients treated with cannabidiol were diarrhea, somnolence, and decreased appetite. These effects were dose-dependent. Evidence Rating Level:...
1. No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway. Evidence Rating Level: 2 (Good) Study Rundown: Previous studies suggest associations between febrile seizures and influenza infection, complex febrile seizures and epilepsy, and seizures (particularly febrile) and vaccination (including...
Surgery for Drug-Resistant Epilepsy in Children The role of surgery in cases of drug-resistant recalcitrant epilepsy in children and adolescents is currently unclear.  In this randomized control trial, 116 patients age 18 years or younger were randomized to receive neurosurgery and medical therapy or medical therapy alone to determine whether...
1. In a Norwegian nationwide registry study, children with epilepsy were compared to the general population. Over three-quarters of children with epilepsy had at least 1 comorbid neurologic, medical, or psychologic disorder compared to less than a third in the general population. 2. Children with more complicated epilepsies had even...
1. Among patients with drug-resistant temporal lobe epilepsy not associated with a brain lesion, focally elevated levels of glutamate were detected to correctly lateralize the epileptogenic focus using glutamate chemical exchange saturation transfer (GluCEST) imaging. 2. No significant differences in hippocampal volumes were detected between the hemispheres of affected patients,...