Tag: estrogen

1. The use of long-term transdermal estrogen for castration therapy for prostate cancer showed no difference in cardiovascular events versus current standard of care. 2. Gynecomastia was significantly more common in the transdermal estrogen group than standard of care group. Evidence Rating Level: 1 (Excellent) Study Rundown: Prostate cancer, an ongoing major...
1. In this pair of identical phase 3 trials involving premenopausal women with uterine fibroids, both elagolix with and without add-back therapy was more effective in reducing heavy menstrual bleeding than placebo. 2. Significant decreases in bone mineral density were observed in the group that received elagolix without add-back therapy,...
1. In this pair of identical phase 3 trials involving premenopausal women with uterine fibroids, both elagolix with and without add-back therapy was more effective in reducing heavy menstrual bleeding than placebo. 2. Significant decreases in bone mineral density were observed in the group that received elagolix without add-back therapy,...
Breast cancer is the most common cancer seen in females, though it is rare in males. Transgender individuals experience incongruence between the sex assigned to them at birth and their experienced or expressed gender. Within this patient population, there has been an increase in the number of referrals for...
Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study...
Image: PD 1. From a model of simulated health outcomes based on the Women’s Health Initiative (WHI) estrogen plus progestin trial, the net economic return of the study was about $37.1 billion, or $140 per dollar invested Evidence Rating Level: 2 (Good)  Study Rundown: Although publicly funded research frequently evaluates patient outcomes,...
Image: PD  1. Compared to oral estradiol use, oral conjugated equine estrogen (CEE) use was associated with an increased incidence of venous thrombosis in postmenopausal women. 2. Biological tests demonstrated that CEE users expressed a greater propensity for clotting than oral estradiol users. .   Evidence Rating Level: 3 (Average)         Study...
Image: PD 1. In men, androgen deficiency was associated with decreases in lean body mass, muscle size, and strength while estrogen deficiency led to increases in body fat. Both appear to regulate sexual function in men.  2. The level of testosterone required to maintain lean body mass, fat mass, strength, and...
Image: PD  1. Androgen deprivation therapy increases the risk of acute kidney injury in patients with non-metastatic prostate cancer.  2. Past use of androgen deprivation therapy did not significantly increase the risk of acute kidney injury.  Evidence Rating Level: 3 (Average)  Study Rundown: Androgen deprivation therapy (ADT) effectively creates a hypogonadal state for...