Tag: kidney transplant

1. PPI use may be associated with an increased mortality risk in patients who have received kidney transplants. Evidence Rating Level: 1 (Excellent) Proton-pump inhibitors (PPIs) are commonly prescribed to kidney transplant recipients (KTRs) to protect against gastrointestinal symptoms and complications induced by their immunosuppressive therapy. Although PPIs are generally well-tolerated,...
The association between use of proton-pump inhibitors and excess mortality after kidney transplantation: A cohort study 1. PPI use may be associated with an increased mortality risk in patients who have received kidney transplants. Evidence Rating Level: 1 (Excellent) Proton-pump inhibitors (PPIs) are commonly prescribed to kidney transplant recipients (KTRs) to protect...
1. Use of HCV-infected kidneys increased patients’ quality-adjusted life expectancy. 2. Lower costs were associated with HCV-infected kidneys compared to transplanting HCV-uninfected kidneys to HCV-positive patients. Evidence Rating Level: 2 (Good) Study Rundown: Organ availability for transplantation is limited; therefore, for patients with end stage renal disease (ESRD), hemodialysis is often the...
1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD). 2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced...
1. Donation with HLA-incompatible kidney confers a survival benefit as compared to staying on the waitlist indefinitely and also staying on the transplant waitlist and subsequently being transplanted with a deceased donor graft. 2. This survival benefit was statistically significant through 8 years of follow-up post transplantation. Evidence Rating Level:...
Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors Many patients in the United States with anti-HLA antibodies remain on kidney transplantation waiting lists for long periods. A report from a single center found a survival benefit from receiving a kidney transplant from a HLA-incompatible live donor compared with remaining...
1. Seven years after transplantation, patient and kidney graft survival and function were significantly higher with belatacept than cyclosporine based immunosuppressants. 2. The cumulative frequencies of serious adverse events were similar across both belatacept and cyclosporine groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Renal transplant immunosuppressive therapies usually include calcineurin-inhibitors, like...
1. The rate of delayed graft function in kidney transplant recipients is significantly reduced by hypothermia prior to implantation. 2. Kidney transplant recipients that benefit most from hypothermia prior to implantation are those from the “expanded-criteria” donation category. Evidence Rating Level: 1 (Excellent)       Study Rundown: Therapeutic hypothermia has been previously...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. HIV-Positive-to-HIV-Positive Kidney Transplantation – Results at 3 to 5 Years Past studies have shown that the outcomes of renal transplantation in HIV-positive patients are comparable to those of other high-risk candidates. In...
1. HIV-positive patients receiving kidney transplants from HIV-positive donor patients experienced a 5-year cumulative survival of 74% and a 5-year cumulative graft survival of 84%. 2. After 5 years of follow-up, HIV-positive patients receiving kidney transplants from HIV-positive donors had viral load levels that remained undetectable. Evidence Rating Level:...