Tag: LDL

1. Exclusive breastfeeding in the first 3 months of life, as opposed to mixed breast and bottle feeding and exclusive bottle feeding, was associated with lower low-density lipoprotein (LDL) cholesterol and lower total cholesterol in adolescence. 2. There was no association between exclusive breastfeeding and body mass index (BMI) or...
1. In addition to significantly lowering levels of low density lipoprotein cholesterol (LDL-C), evolocumab reduced the composite risk of cardiovascular events in atherosclerotic patients on optimal statin therapy without a significant increase in adverse effects. 2. As individual endpoints, evolocumab did not significantly reduce the rate of either cardiovascular or...
1. Greater severity of weight class in pediatric patients associated with higher risk ratios of cardiometabolic risk factors including systolic and diastolic blood pressure (BP), HbA1c and triglycerides.  2. Male participants in higher obesity classes more likely to show significant differences in cardiometabolic risk factors, compared to female participants Evidence Rating:...
1. In patients on maximal statin treatment and with LDL levels over 70mg/dL, the addition of alirocumab reduced LDL levels from baseline by about 62% compared to placebo. 2. No increase in adverse events was noted with alirocumab compared to placebo. Evidence Rating Level: 1 (Excellent)       Study Rundown: People...
1. Compared to those treated with only standard therapy, patients treated with the addition of evolocumab, a monoclonal antibody that inhibits activity of proprotein convertase subtilisin-kexin type 9 serine protease (PCSK9), experienced significantly lower serum LDL levels and lower rates of cardiovascular events at 1 year compared to placebo. 2....
1. Genetic mutations that led to the inactivation NPC1L1, a lipid transporter protein, were linked to lower low-density lipoprotein (LDL) and total cholesterol levels. Evidence Rating Level: 2 (Good) Study Rundown: Ezetimibe is a lipid-lowering agent thought to block lipid absorption by inhibiting the Niemann-Pick C1-like 1 gene (NPC1L1),...
1. Complete lack of endogenous Apolipoprotein E (apoE) was associated with altered lipid metabolism, including high cholesterol. 2. Lack of apoE was not associated with neurocognitive or visual deficits. Evidence Rating Level: 4 (Poor) Study Rundown: Apolipoprotein E (apoE) is a molecule expressed both in the astrocytes of the brain and in...