Tag: LDL

1. Evinacumab significantly lowered low-density lipoprotein (LDL) cholesterol levels in patients with homozygous familial hypercholesterolemia. 2. Patients receiving evinacumab did not demonstrate additional serious adverse events compared to the control group. Evidence Rating Level: 1 (Excellent) Study Rundown: Homozygous familial hypercholesterolemia occurs due to a loss-of-function variant in the low-density lipoprotein (LDL)...

1. Evinacumab significantly lowered low-density lipoprotein (LDL) cholesterol levels in patients with homozygous familial hypercholesterolemia. 2. Patients receiving evinacumab did not demonstrate additional serious adverse events compared to the control group. Evidence Rating Level: 1 (Excellent) Study Rundown: Homozygous familial hypercholesterolemia occurs due to a loss-of-function variant in the low-density lipoprotein (LDL)...

1. Targeting a lower LDL does not impact carotid plaque incidence but does increase the rate of regression of pre-existing atherosclerotic lesions among patients who have experienced an ischemic stroke. Evidence Rating Level: 2 (Good) Low-density lipoprotein (LDL) is a lipid molecule that has been implicated in the development of atherosclerotic...

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1. Inclisiran, a small interfering RNA, therapy was shown to significantly lower levels of low-density lipoprotein (LDL) cholesterol compared to the placebo in adults with heterozygous familial hypercholesterolemia. 2. The reduction in LDL cholesterol levels, via inclisiran therapy, was shown to be similar to the reduction achieved with proprotein convertase...

1. Inclisiran, a small interfering RNA, therapy was shown to significantly lower levels of low-density lipoprotein (LDL) cholesterol compared to the placebo in adults with heterozygous familial hypercholesterolemia. 2. The reduction in LDL cholesterol levels, via inclisiran therapy, was shown to be similar to the reduction achieved with proprotein convertase...

1. This randomized controlled trial showed that patients with ischemic stroke or transient ischemic attack with target LDL levels of less than 70 mg/dL had lower rates of subsequent cardiovascular events when compared to target LDL levels of 90 to 110 mg/dL.  2. Patients were provided with a statin and...

1. This randomized controlled trial showed that patients with ischemic stroke or transient ischemic attack with target LDL levels of less than 70 mg/dL had lower rates of subsequent cardiovascular events when compared to target LDL levels of 90 to 110 mg/dL.  2. Patients were provided with a statin and...

1. In this serial, cross-sectional analysis, US youths had improved triglycerides, LDL, HDL, and total cholesterol from 1999 to 2016. 2. While half of all US youths had ideal lipid levels, nearly a quarter had at least one unfavorable lipid measure. Evidence Rating Level: 2 (Good) Study Rundown: Optimal lipid levels help...

1. In this retrospective cohort study of adults under age 50 with myocardial infarction, 9% met criteria for definite or probable familial hypercholesterolemia, which is roughly 20x the prevalence in the general American population. 2. Only about two-thirds of patients with familial hypercholesterolemia and myocardial infarction were discharged on high...