• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Elevated LDL cholesterol associated with increased risk of myocardial infarction and ASCVD in individuals aged 70-100 years

byMichael PratteandTeddy Guo
December 14, 2020
in Cardiology, Chronic Disease
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In individuals aged 70-100 years, there was a significantly increased risk of myocardial infarction and atherosclerotic cardiovascular disease for every 1.0 mmol/L increase in LDL cholesterol.

2. Individuals aged 80-100 years were found to have the lowest number needed to treat in 5 years to prevent one myocardial infarction.

Evidence Rating Level: 2 (Good)

Study Rundown: Atherosclerotic cardiovascular disease (ASCVD) is a major driver of morbidity and mortality around the world. Levels of LDL cholesterol are widely acknowledged as an important risk factor in the development of ASCVD and targeting healthy LDL values is a mainstay in the management of cardiovascular conditions. Although many guidelines currently recommend the treatment of elevated LDL levels, most do not recommend doing so beyond the age of 70 years. This primary prevention cohort study monitored LDL levels and incidence of ASCVD and myocardial infarction (MI) in individuals aged 20-100 years to determine if an association existed beyond the age of 70 years. Overall, elevated LDL cholesterol was strongly associated with incidence of ASCVD and MI in all age groups, particularly those aged 70-100 years. Amongst individuals with LDL>5.0mmol/L, MI risk was four times higher in those aged 80-100 versus those aged 20-69. The number needed to treat (NNT) in 5 years to prevent one MI was lowest for individuals aged 80-100 years and highest in those aged 20-49 years. A strength of this study is its large sample size and robust follow-up rate. An important limitation, however, is the exclusive inclusion of individuals of white European (Danish) descent as incidence of cardiovascular disease may vary across different ethnicities. Likewise, findings must be interpreted in the context that ASCVD is nearly ubiquitous and found in a large portion of patients seen in hospital and clinic; thus, these results would be less applicable.

Click to read the study in The Lancet

Relevant Reading: Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials.

In-Depth [prospective cohort]: This primary prevention cohort study enrolled 91 131 individuals aged 20-100 years from the Danish general population as part of the Copenhagen General Population Study (CGPS) (n=3188, 80-100 years old). Participants were of a white European ethnic background of Danish descent and did not have a pre-existing history of ASCVD, diabetes, or statin use. The primary endpoints of this study were incidence of MI and ASCVD. Overall, for every 1.0 mmol/L increase in LDL cholesterol, there was an increased risk of MI (Hazard ratio [HR] = 1.34, 95% CI 1.27-1.41) and ASCVD (HR = 1.16, 95% CI 1.12-1.21) across all age groups. Compared to those with LDL levels < 3 mmol/L, individuals aged 80-100 years with LDL levels ≥ 5.0 mmol/L had a nearly 3- and 2-fold increased risk for MI (HR = 2.99, 95% CI 1.71-5.23) and ASCVD (HR = 1.90, 1.27-2.83), respectively. In individuals with an LDL ≥ 5.0 mmol/L, the MI event rate was nearly four times greater in those aged 80-100 years compared to those aged 20-69 years (multivariable adjusted HR = 3.7, 95% CI 1.6-8.8). NNT in 5 years was based on a relative risk reduction of 30% for MI and 22% for ASCVD per 1mmol/L LDL level drop using moderate-intensity statin therapy. Overall, NNT for MI risk reduction was 80 in ages 80-100, 145 for 70-79, 261 for 60-69 and 439 for 50-59. NNT for ASCVD risk reduction was 42 in ages 80-100, 88 for 70-79, 164 for 60-69 and 345 for 50-59.  Taken together, these findings produce strong support for the consideration of LDL reduction for ASCVD and MI risk prevention in individuals aged 70-100 years.

RELATED REPORTS

Febuxostat may be effective in preventing contrast-induced acute kidney injury

72- and 36-hour fever prevention post-cardiac arrest equivalent in preventing mortality

Synergistic interaction between risk burden and genetics for atrial fibrillation development

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: atherosclerosiscardiologyLDLlow density lipoprotein (LDL)myocardial infarction (MI)
Previous Post

Perioperative levels of BNP associated with postoperative atrial fibrillation risk after noncardiac surgery

Next Post

Fixed low dose of erythropoeitin associated with similar efficacy outcomes as as titration-based dosing

RelatedReports

Being overweight and obese associated with increased incidence of chronic kidney disease
Cardiology

Febuxostat may be effective in preventing contrast-induced acute kidney injury

March 27, 2023
Cardiac mortality paradoxically lower during times of national cardiology conferences
Cardiology

72- and 36-hour fever prevention post-cardiac arrest equivalent in preventing mortality

March 24, 2023
Rivaroxaban likely reduces risk of recurrent stroke in specific subgroup of patients with embolic stroke of undetermined source
Cardiology

Synergistic interaction between risk burden and genetics for atrial fibrillation development

March 21, 2023
Intensive rehabilitation not superior to traditional therapy for arm function after stroke
Weekly Rewinds

2 Minute Medicine Rewind March 20, 2023

March 20, 2023
Next Post
No association found between length of storage for transfused red blood cells and patient mortality

Fixed low dose of erythropoeitin associated with similar efficacy outcomes as as titration-based dosing

Probiotics improve colic, reduce GI disorders in infants

Meta-analysis highlights health benefits of probiotics and prebiotics in premature infants

Quick Take: Dual-Energy Computed Tomography Detection of Cardiovascular Monosodium Urate Deposits in Patients With Gout

Febuxostat is not associated with worse cardiovascular safety outcomes or all-cause mortality compared to allopurinol

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • SAR-CoV-2 infection during pregnancy may lead to adverse neurodevelopmental outcomes in male offspring
  • Hyperfractionated radiotherapy reduces complication rates compared to standard fractionation for locally advanced nasopharyngeal carcinoma
  • Lebrikizumab effective in treating moderate-to-severe atopic dermatitis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options