Tag: lenalidomide

1. Induction therapy and maintenance therapy for mantle-cell lymphoma with lenalidomide plus rituximab was found to be effective and safe. 2. A response to treatment with these biologic agents was associated with improvement in quality of life. Evidence Rating Level: 2 (Good)           Study Rundown: Mantle-cell lymphoma is generally...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011 Despite studies showing similar survival for patients with early-stage breast cancer treated with breast-conserving...
1. Progression-free survival was improved by about 3 months with continuous lenalidomide-dexamethasone compared to standard melphalan-prednisone-thalidomide. 2. Overall survival was also better with continuous lenalidomide-dexamethasone compared to melphalan-prednisone-thalidomide. Evidence Rating Level: 1 (Excellent) Study Rundown: Multiple myeloma (MM) is a disease of plasma cells. Over proliferation of these antibody-producing...
1. The addition of lenalidomide to standard R-CHOP chemotherapy reduced the negative prognostic impact of non-GCB phenotype in diffuse large B-cell lymphoma (DLBCL) progression-free and overall survival. Evidence Rating Level: 1 (Excellent)  Study Rundown: Therapy for diffuse large B-cell lymphoma (DLBCL) has advanced in recent years with the introduction of dose-intensified...
Image: PD 1. Most treatment-naïve patients with chronic lymphocytic leukemia (CLL) safely tolerated escalating doses of combined lenalidomide and rituximab. 2. Younger patients showed higher response rates but similar progression free survival compared to older patients. Evidence rating level: 1 (Excellent) Study rundown: Some patients with chronic lymphocytic leukemia (CLL), particularly older patients and...
In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery In this randomized control trial, 400 patients with intermediate to high risk of pulmonary complications after major abdominal surgery were randomized to...
Image: CC/Osaro 1. Treatment with lenalidomide and dexamethasone significantly delayed disease progression in patients with smoldering multiple myeloma who were at high risk for progression. 2. Treatment with lenalidomide and dexamethasone improved survival in such patients. 3. The treatment was associated with more adverse events than observation (current standard). Evidence Rating Level: 1...