Tag: Lupus

1. A significantly greater proportion of patients in the voclosporin group achieved complete renal responses after 52 weeks compared to the placebo group. 2. The safety profile between the voclosporin group and placebo group were comparable with 21% of patients in both groups experiencing serious adverse events. Evidence Rating Level: 1...
1. In this retrospective cohort study, the authors observed that the greater decline in in-hospital maternal mortality was found for systemic lupus erythematosus (SLE) pregnancies compared to non-SLE pregnancies. 2. Despite reductions in in-hospital maternal mortality for SLE pregnancies, the rates still remain high and improvements are needed. Evidence Rating Level:...
Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence Major depressive disorder (MDD) affects a significant number of patients with chronic kidney disease (CKD). Due to safety concerns, these patients have been largely omitted from clinical trials evaluating the efficacy of commonly used antidepressants....
1. Over the 46-year study period, systemic lupus erythematosus (SLE) age-standardized mortality rates (ASMRs) did not decline as much as non-SLE ASMR, and there was a 34.6% cumulative growth in the ratio of SLE to non-SLE ASMR. 2. SLE ASMRs were higher in the elderly, females, black and Hispanic individuals,...
Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder Among Veterans Post Traumatic Stress Disorder (PTSD) is a common mental health disorder in veterans and other individuals who experience traumatic events. Mindfulness-based intervention has been shown to be effective in major depressive disorder and is thought to be beneficial in PTSD as...
1. From a prospective cohort study, adverse pregnancy outcomes in lupus patients were associated with the presence of lupus anticoagulant, antihypertensive use, and a higher Physician’s Global Assessment score. 2. Absent these risk factors, adverse pregnancy outcomes occurred rarely in patients with stable mild or moderate lupus. Evidence Rating Level: 2...
Originally published by Harvard Health. What Is It? Lupus is thought to develop when your body's immune system mistakenly attacks the body's own tissues.  . Immune proteins called autoantibodies attack many different parts of the body, causing inflammation and tissue damage in many parts of the body, including the joints, skin,...
1. Multi-target induction therapy for lupus nephritis with mycophenolate mofetil, tacrolimus, and steroids increased remission rates after 24 weeks compared to IV cyclophosphamide and steroids. 2. More patients in the multi-target treatment group dropped out due to adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Current induction therapy regimens for lupus...