Tag: methotrexate

1. In patients with different types of morphea unresponsive to phototherapy and methotrexate, mycophenolate appears to be a safe and beneficial treatment option. Evidence Rating: 2 (Good) Morphea, otherwise known as localized scleroderma, is a rare sclerosing disorder of the skin affecting patients of all ages. Currently, first-line systemic therapy typically...
1. Treatment with biologics in pediatric patients with moderate to severe psoriasis was significantly associated with greater reduction in psoriasis severity than methotrexate, though methotrexate remains an effective treatment for the condition. Evidence Rating: 2 (Good) Psoriasis is a highly debilitating chronic inflammatory skin disorder that affects up to 1.37% of children,...
1. Treatment with biologics in pediatric patients with moderate to severe psoriasis was significantly associated with greater reduction in psoriasis severity than methotrexate, though methotrexate remains an effective treatment for the condition. Evidence Rating: 2 (Good) Psoriasis is a highly debilitating chronic inflammatory skin disorder that affects up to 1.37% of...
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial 1. Study findings suggest that early administration of intravenous dexamethasone during acute respiratory distress syndrome may decrease duration of mechanical ventilation and mortality rates. Evidence Level: 1 (Excellent) Acute respiratory distress syndrome (ARDS), characterized by acute hypoxemic respiratory failure...
1. At 6 months, patients receiving tofacitinib monotherapy had reduced structural joint damage compared to methotrexate monotherapy.  2. Patients treated with tofacitinib had increased numbers of adverse events, including herpes zoster infections and creatinine and lipid elevations. Evidence Rating Level: 1 (Excellent) Study Rundown: This randomized, controlled study was designed to compare...
Image: PD 1. Atorvastatin administration for both healthy donors and recipients of matched sibling allogeneic hematopoietic cell transplantation (HCT) represents feasible and safe potential acute GVHD prophylaxis. 2. Further investigation is needed to determine the effectiveness of this strategy. Evidence rating level: 2 (Good)  Study Rundown: Acute graft-versus-host disease (GVHD) causes significant morbidity...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Riociguat for the Treatment of Pulmonary Arterial Hypertension In this phase III, double-blinded randomized control trial, investigators randomized patients with pulmonary arterial hypertension (n = 443) to riociguat, a guanylate...
Image: PD 1. Visual acuity improvement was much higher with interferon beta therapy compared to methotrexate therapy (p=0.0435). 2. Macular thickness was significantly decreased in patients treated with interferon beta (p=0.0039), but increased in patients treated with methotrexate. Evidence Rating Level: 1 (Excellent) Study Rundown: This study demonstrates the increased efficacy of interferon...