• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

A Comparison of Psoriasis Severity in Pediatric Patients Treated With Methotrexate vs Biologic Agents

byAlex ChanandRavi Shah, MD MBA
February 22, 2020
in Chronic Disease, Dermatology, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Risk of hydroxychloroquine retinopathy increases with longer use and higher dosage

Bimekizumab is effective for active psoriatic arthritis in biologic-naĂŻve adults

Olokizumab is noninferior to adalimumab for the treatment of rheumatoid arthritis

1. Treatment with biologics in pediatric patients with moderate to severe psoriasis was significantly associated with greater reduction in psoriasis severity than methotrexate, though methotrexate remains an effective treatment for the condition.

Evidence Rating: 2 (Good)

Psoriasis is a highly debilitating chronic inflammatory skin disorder that affects up to 1.37% of children, with its highly visible nature contributing to significantly impaired quality of life and necessitating therapy. While most cases of psoriasis are responsive to topical therapy, 20% of children have more severe forms of the disease that require systemic therapy. Methotrexate is currently the most commonly prescribed and least expensive disease modifying anti-rheumatic drug. While multiple biologic agents have been approved as alternative treatment options, no investigations have prospectively compared their efficacy against methotrexate, aside from a previous study that found adalimumab to be a potentially superior option. In this retrospective cohort study, clinical data from 234 pediatric patients with moderate to severe psoriasis who had received at least 3 months of biologic or methotrexate treatment were analyzed. Primary outcome measures were the Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA) as operational measures of psoriasis severity and responsiveness to treatment. A PASI75 score indicates 75% or greater improvement and PGA0/1 represents a clear or minimal assessment. Drug survival rates were additionally analyzed. At 6 months follow up, 75% or greater improvement in PASI was achieved in 71.4% of patients receiving biologic agent treatment versus 40% in the methotrexate group. Likewise, achievement of PASI75 or PGA0/1, and decreased mean PASI and PGA scores were more strongly associated with biologic agent usage than methotrexate. Finally, after 1, 3, and 5 years of use, overall drug survival rates for methotrexate were 77.5%, 50.3%, and 35.9% versus 83.4%, 64.3%, and 57.1% for biologic agents, demonstrating a significantly higher survival rate for biologics than methotrexate (HR, 2.23; 95% CI, 1.21-4.10; p = .01). Prior research has found biologics to be additionally associated with fewer treatment related toxic effects and requiring less monitoring during administration. As such, while methotrexate remains a cost-effective strategy in the treatment of moderate to severe psoriasis, study findings suggest that biologic treatment may be a more effective and safe treatment option when compared to methotrexate, with the caveat of being more expensive.

Click to read the study in JAMA Dermatology

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Biologic disease-modifying anti-rheumatic drugs (bDMARDsbiologicsDMARDmethotrexatepsoriasis
Previous Post

Effect of Hydrocortisone vs Pasireotide on Pancreatic Surgery Complications in Patients With High Risk of Pancreatic Fistula

Next Post

Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality

RelatedReports

Blindness and visual impairment decreasing worldwide
Chronic Disease

Risk of hydroxychloroquine retinopathy increases with longer use and higher dosage

February 1, 2023
Long-term use of apremilast for psoriasis associated with an acceptable safety profile
Chronic Disease

Bimekizumab is effective for active psoriatic arthritis in biologic-naĂŻve adults

January 24, 2023
2 Minute Medicine Rewind January 28, 2019
Chronic Disease

Olokizumab is noninferior to adalimumab for the treatment of rheumatoid arthritis

August 26, 2022
2 Minute Medicine Rewind January 28, 2019
Chronic Disease

Methotrexate reduces functional burden of disease in patients with arthralgia at-risk of developing rheumatoid arthritis

August 3, 2022
Next Post
Provision of medically-tailored meals linked with lower admissions and medical spending

Associations of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake With Incident Cardiovascular Disease and All-Cause Mortality

Dexamethasone treatment for the acute respiratory distress syndrome

Dexamethasone treatment for the acute respiratory distress syndrome

Cognitive outcomes in older adults undergoing cardiovascular procedures unclear

Long-Term Outcomes Associated With Total Arterial Revascularization vs Non-Total Arterial Revascularization

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Metformin use may decrease risk of osteoarthritis development
  • Intensive blood pressure lowering by non-physician healthcare providers significantly reduces the risk of cardiovascular disease
  • Expectant management of patent ductus arteriosus noninferior to early ibuprofen use
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options