1. Breast tumors with stem cell mutations in the PI3K/Akt signaling pathway had significantly higher rates of axillary lymph node metastases.
2. Among women with breast tumors with stem cell mutations, 30% experienced disease progression after treatment and 20% died from the disease, compared to 0% in women with...
1. Mutations in the colony-stimulating factor 3 receptor (CSF3R) gene were found in a majority of samples of neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (CML).
2. Different types of CSF3R mutations are associated with vulnerability to different therapeutics in vitro and potentially in vivo.
Study Rundown: Aberrant kinases...