#VisualAbstract: Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis
1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain ...
Tag: osteoarthritis
MIV-711 effective in reducing bone and cartilage manifestations for patients with osteoarthritis
1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain ...
#VisualAbstract: Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee
1. In this randomized controlled trial, subcutaneous tanezumab resulted in moderate improvements in joint pain and physical function for patients ...
Quick Take: The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT)
The two main surgical options for late-stage medial compartment osteoarthritis of the knee are partial knee replacement (PKR) and total ...
Tanezumab provides modest benefit for osteoarthritis
1. In this randomized controlled trial, subcutaneous tanezumab resulted in moderate improvements in joint pain and physical function for patients ...
#VisualAbstract: Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis
1. In this retrospective cohort of patients with osteoarthritis, tramadol had a significantly higher risk of mortality over 1 year ...
Tramadol may be associated with increased mortality among patients with osteoarthritis
1. In this retrospective cohort of patients with osteoarthritis, tramadol had a significantly higher risk of mortality over 1 year ...
Long-term glucosamine sulfate likely improves pain and function in knee osteoarthritis
1. In this systematic review and meta-analysis of patients with knee osteoarthritis (OA) receiving a variety of pharmacologic treatments, glucosamine ...
Inhibiting mitochondrial responses after intra-articular fracture slows progression of posttraumatic osteoarthritis
1. Intra-articular fractures (IAFs) often lead to posttraumatic osteoarthritis (PTOA) through mechanisms that involve mitochondria. 2. In a porcine model ...
Hydroxychloroquine shows no greater effectiveness than placebo for hand osteoarthritis pain
1. For radiographic osteoarthritis and hand pain that is moderate to severe, hydroxychloroquine (HCQ) does not show any greater effectiveness ...
