Tag: Parkinson’s

1. Patients that received deep brain stimulation (DBS) surgery demonstrated significantly greater decline in neuropsychological function within 6 months when compared to patients having received no surgery. 2. Of patients receiving DBS, 11% displayed multi-domain cognitive decline (MDCD), which was associated with a negative effect on patient quality of life. Evidence...

1. Deep brain stimulation (DBS) has established effectiveness in the treatment of medication-refractory Parkinson disease, and in patients with significant motor fluctuations and dyskinesia.  2. The rate of complications from DBS did not correlate with increased age, suggesting that older patients, who are typically not considered to be candidates for DBS,...

1. Levodopa provided a small but consistent benefit for treatment of Parkinson’s disease as compared to levodopa-sparing regimens including dopamine agonists and monoamine oxidase B inhibitors (MAOBIs).  2. Among levodopa sparing regimens, MAOBIs were at least as effective as dopamine agonists.  Evidence Rating Level: 2 (Good)             Study...

Feb 14th - Neurostimulation improved quality of life for Parkinson’s disease patients with early levodopa-induced motor complications.  Image: CC/Hellerhoff 1. Neurostimulation improved quality of life for Parkinson’s disease patients with early levodopa-induced motor complications. The study showed that neurostimulation could improve quality of life when given in combination with medical therapy for...