Tag: preeclampsia

1. Obesity was associated with recurrent preeclampsia among pregnant women during their first and subsequent pregnancies. 2. Diabetes mellitus, chronic hypertension and being overweight were found to be risk factors for incident and recurrent preeclampsia. Evidence Rating Level: 1 (Excellent) Study Rundown: Preeclampsia is a disorder that affects approximately 8% of pregnancies...
1. COVID-19 infection during pregnancy was associated with consistent and substantial increases in severe maternal morbidity and mortality and neonatal complications compared to non-infected pregnancies, especially in symptomatic individuals presenting or those with co-morbidities. 2. Women with COVID-19 were at increased risk of severe pregnancy complications including pre-eclampsia/eclampsia, intensive care...
1. The one-step screening method increased the incidence of diagnosis compared to the two-step screening method for gestational diabetes. 2. No significant difference was found between the two screening methods for risk of adverse perinatal outcomes, gestational hypertension, and preeclampsia. Evidence Rating Level: 1 (Excellent) Study Rundown: There is a lack of...
1. Mothers with preterm deliveries have significantly different levels of metabolites among them compared to term mothers. 2. There are different levels of metabolites among mothers with spontaneous preterm deliveries and with medically-indicated spontaneous preterm deliveries with or without preeclampsia. Evidence Rating Level: 2 (Good) Mothers who have preterm deliveries (PTD) may...
1. Maternal preeclampsia at term was associated with an increased risk of neurodevelopmental disorders in offspring. Evidence Rating: 1 (Excellent) While the risks associated with preeclampsia are well established for the mother, the associated outcomes and risks for the offspring are relatively less well characterized. Preeclampsia has previously been linked to cerebral...
Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial 1. Patients receiving landiolol were more likely to achieve target heart rates of 60-94 following sepsis-related tachyarrhythmia and had significantly reduced incidence of new onset arrhythmia Evidence Rating: 1...
1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by the placenta. 2. Designer short interfering RNAs (siRNAs) that target particular sFLT1 mRNA isoforms were shown to accumulate in the placenta and prevent the hypertension and proteinuria associated with preeclampsia. Evidence...
While obesity has been shown to increase the risk of developing gestational diabetes mellitus (GDM) and preeclampsia (PE) in pregnancy, the association between metabolic syndrome and adverse pregnancy outcomes has not been investigated. In this multicenter prospective cohort study, 5,530 nulliparous women with singleton pregnancies recruited between November 2004...
1. Women experiencing hypertensive disorders of pregnancy (HDP) had higher rates of cardiovascular disease persisting following the pregnancy. 2. Women with HDP were at particular risk for chronic hypertension, type 2 diabetes (T2DM), and high cholesterol. Evidence Rating Level: 2 (Good) Study Rundown: HDP largely includes pre-eclampsia and gestational hypertension. The literature...
1. Low-dose aspirin significantly reduced the incidence of preterm preeclampsia in women identified as high-risk for preeclampsia using a screening protocol that combined maternal factors with biochemical measurements at 11-13 weeks of gestation. 2. No significant differences in adverse outcomes were found in women given low-dose aspirin compared to placebo. Evidence...