Tag: preeclampsia

1. Mothers with preterm deliveries have significantly different levels of metabolites among them compared to term mothers. 2. There are different levels of metabolites among mothers with spontaneous preterm deliveries and with medically-indicated spontaneous preterm deliveries with or without preeclampsia. Evidence Rating Level: 2 (Good) Mothers who have preterm deliveries (PTD) may...
1. Maternal preeclampsia at term was associated with an increased risk of neurodevelopmental disorders in offspring. Evidence Rating: 1 (Excellent) While the risks associated with preeclampsia are well established for the mother, the associated outcomes and risks for the offspring are relatively less well characterized. Preeclampsia has previously been linked to cerebral...
Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial 1. Patients receiving landiolol were more likely to achieve target heart rates of 60-94 following sepsis-related tachyarrhythmia and had significantly reduced incidence of new onset arrhythmia Evidence Rating: 1...
1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by the placenta. 2. Designer short interfering RNAs (siRNAs) that target particular sFLT1 mRNA isoforms were shown to accumulate in the placenta and prevent the hypertension and proteinuria associated with preeclampsia. Evidence...
While obesity has been shown to increase the risk of developing gestational diabetes mellitus (GDM) and preeclampsia (PE) in pregnancy, the association between metabolic syndrome and adverse pregnancy outcomes has not been investigated. In this multicenter prospective cohort study, 5,530 nulliparous women with singleton pregnancies recruited between November 2004...
1. Women experiencing hypertensive disorders of pregnancy (HDP) had higher rates of cardiovascular disease persisting following the pregnancy. 2. Women with HDP were at particular risk for chronic hypertension, type 2 diabetes (T2DM), and high cholesterol. Evidence Rating Level: 2 (Good) Study Rundown: HDP largely includes pre-eclampsia and gestational hypertension. The literature...
1. Low-dose aspirin significantly reduced the incidence of preterm preeclampsia in women identified as high-risk for preeclampsia using a screening protocol that combined maternal factors with biochemical measurements at 11-13 weeks of gestation. 2. No significant differences in adverse outcomes were found in women given low-dose aspirin compared to placebo. Evidence...
1. Among women with gestational hypertension, those who breastfed had lower postpartum blood pressures than those who did not. 2. Breastfeeding was not associated with differences in postpartum blood pressure in women with preeclampsia or those with normotension in pregnancy. Evidence Rating Level: 1 (Excellent) Study Rundown: Hypertensive disorders of pregnancy, which...
  1. Preeclampsia is a partially understood condition in which circulating maternal serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1) are increased and placental growth factor (PlGF) levels are decreased. 2. sFlt-PlGF ratios of 38 or lower had a negative predictive value of 99.3% for the outcome of no...
1. Women with pre-eclampsia randomized to magnesium experienced a greater than 50% reduction in eclampsia compared to women on placebo. Original Date of Publication: June 2002 Study Rundown: Pre-eclampsia is a multi-system hypertensive disorder of pregnancy associated with significant maternal morbidity and mortality. Worldwide, approximately 50 000-60 000 women die from...