Quantifying the increased mortality associated with delayed antibiotics in pediatric sepsis
1. Administration of antibiotics beyond 330 minutes from emergency department arrival in pediatric patients with sepsis was associated with increased ...
Tag: sepsis
Early de-escalation from intravenous to oral antibiotics may be appropriate for uncomplicated gram-negative bacteremia
1. In this cohort study, patients with uncomplicated gram-negative bacteremia who were switched from intravenous (IV) to oral antibiotics demonstrated ...
The 2 Minute Medicine Podcast Episode 20
Welcome to the 2 Minute Medicine Podcast, summarizing the latest medical studies, curated and written by practicing physicians. On this ...
The Scan by 2 Minute Medicine®: Pre-Eclampsia Prevention, BMI No More, Madonna’s Sepsis Scare, Presidential Controversy, and Injuries of the Tour de France
The Scan by 2 Minute Medicine® is a pop-culture medical newsletter and exclusive benefit for 2 Minute Medicine Plus subscribers. ...
No advantage of continuous vs intermittent meropenem in critically ill patients – the MERCY trial
1. The MERCY trial revealed that continuous infusion of meropenem does not confer a significant advantage over intermittent administration in ...
Shorter antibiotic therapy courses likely noninferior in the treatment of complicated urinary tract infections and bacteremia
1. In bacteremic patients with complicated UTI, a 10-day course of typical antibiotics or a 7-day course of IV beta-lactams ...
Higher mean arterial pressure targets may be preferable for patients with sepsis
1. In this retrospective cohort study, patients with sepsis and high-mean arterial pressure (MAP) management had a significantly lower 30-, ...
Early restrictive fluid management does not reduce mortality in sepsis-induced hypotension
1. Early use of vasopressors combined with a conservative fluid resuscitation did not result in a mortality benefit over a ...
Balanced intravenous solutions reduce risk of hyperchloremia in the pediatric intensive care unit
1. In a randomized controlled trial of critically ill pediatric patients requiring intravenous fluid therapy, children receiving saline were significantly ...
