Gene therapy cost-effective for treating sickle cell disease in simulation models
1. In this cost analysis, compared to standard care, it was found that gene therapy for sickle cell disease (SCD) ...
Tag: sickle cell disease
The Scan by 2 Minute Medicine®: UK Approves First CRISPR Treatment, Cardiac Considerations, Pelicans Player Has a Pneumothorax, and Life Expectancy Gaps
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CRISPR-Cas9 promoting fetal hemoglobin production improves severe sickle cell disease
1. In this randomized controlled trial, infusion of OTQ923 disrupted inhibitory HBG1 and HBG2 promoter regions of the gamma-globin gene. ...
Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality
1. Sickle cell trait was associated with increased COVID-19 mortality and various preexisting chronic medical conditions, particularly in persons of ...
LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling hemoglobin, HbAT87Q. 2. LentiGlobin led to reduced hemolysis ...
Hydroxyurea with dose escalation performs better than fixed-dose hydroxyurea in pediatric sickle cell disease
1. Children with sickle cell disease who received the maximum tolerated dose of hydroxyurea had higher concentrations of hemoglobin and ...
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