Tag: urate

1. Urate reduction with allopurinol did not slow the decline of estimated glomerular filtration rate (eGFR) compared to the placebo treatment in patients with chronic kidney disease. 2. The urinary albumin:creatinine ratio was shown not to be significantly different between the treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Increased risk...
1. Serum urate reduction with allopurinol was not shown to clinically benefit kidney function among patients with type 1 diabetes and early-to-moderate diabetic kidney disease. 2. Serum creatinine did not improve following serum urate reduction with allopurinol. Evidence Rating Level: 1 (Excellent) Study Rundown: The lifetime risk of diabetic kidney disease among...
Efficacy and Long-term Peripheral Sensory Neuropathy of 3 vs 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Colon Cancer: The ACHIEVE Phase 3 Randomized Clinical Trial 1. A shortened course of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer was associated with decreased peripheral sensory neuropathy without compromising effectiveness. Evidence Rating Level:...