Tag: Urology

1. Ipatasertib-abiraterone treatment significantly improved progression-free survival compared to placebo-abiraterone in patients with PTEN-loss metastatic castration-resistant prostate cancer. 2. Grade 3 or greater adverse events occurred in 70% of patients treated with ipatasertib plus abiraterone versus 39% in placebo plus abiraterone. Evidence Rating Level: 1 (Excellent) Study Rundown: Metastatic castration-resistant prostate cancer (mCRPC) is currently...

1. Ipatasertib-abiraterone treatment significantly improved progression-free survival compared to placebo-abiraterone in patients with PTEN-loss metastatic castration-resistant prostate cancer. 2. Grade 3 or greater adverse events occurred in 70% of patients treated with ipatasertib plus abiraterone versus 39% in placebo plus abiraterone. Evidence Rating Level: 1 (Excellent) Study Rundown: Metastatic castration-resistant prostate cancer...

1. Among men with symptoms of overactive bladder with or without concomitant benign prostatic hyperplasia, tamsulosin therapy significantly reduced the symptoms of overactive bladder. Evidence Rating Level: 2 (Good) Lower urinary tract symptoms (LUTS) are common among older male adults and are most commonly attributed to either benign prostatic hyperplasic (BPH)...

An exploratory analysis of tamsulosin for Overactive Bladder (OAB) in men with varying voiding symptom burden 1. Among men with symptoms of overactive bladder with or without concomitant benign prostatic hyperplasia, tamsulosin therapy significantly reduced the symptoms of overactive bladder. Evidence Rating Level: 2 (Good) Lower urinary tract symptoms (LUTS) are common...

1. Patients continuing perioperative anticoagulation when undergoing robot-assisted radical prostatectomy did not experience an increased incidence of high-grade bleeding. Evidence Level Rating: 2 (Good) Robot-assisted radical prostatectomy (RARP) is the standard of care for surgical management of localized prostate cancer. As RARP is classified as a hemorrhagic procedure, patients on anticoagulation...

1. Men diagnosed with localized prostate cancer have lower self-reported quality of life outcomes, particularly sexual function in those who underwent radical prostatectomy. 2. Mental well-being was similar between men without prostate cancer and men who underwent active surveillance/watchful waiting or low dose rate brachytherapy, as their primary treatment for...

1. Among those presenting with symptomatic nephrolithiasis, patients electing for trial of passage with medical expulsion therapy were more likely to receive a prescription for an opiate compared with those electing for early surgical intervention. Evidence Rating Level: 3 (Average) Despite a widespread reduction in the number of prescriptions for opioids...

1. For treatment of urgency incontinence, behavioral intervention was associated with the greatest reduction in incontinence episodes and the highest patient satisfaction rates compared to standard drug treatment with oxybutynin or placebo. Original Date of Publication: December 1998 Study Rundown: Urge urinary incontinence is a costly and common diagnosis among the...

1. In a retrospective cohort of 1107 patients with lymph node invasion following primary prostate cancer treatment, the use of adjuvant radiotherapy was associated with a significant improvement in cancer-specific mortality. 2. Two sub-group of patients: 1) Patients with positive lymph node counts of <2, Gleason score 7-10, pT3b/pT4 stage...

1. In a phase I trial, ODM-201 was well tolerated up to 1800mg per day in prostate cancer patients, without reaching the maximum tolerated dose. 2. In a phase II trial, up to 33% of patients randomized to ODM-201 had a 50% or greater decrease in serum PSA at 12...