Tag: Urology

Classics Series, Landmark Trials in Medicine
1. For treatment of urgency incontinence, behavioral intervention was associated with the greatest reduction in incontinence episodes and the highest patient satisfaction rates compared to standard drug treatment with oxybutynin or placebo. Original Date of Publication: December 1998 Study Rundown: Urge urinary incontinence is a costly and common diagnosis among the...
1. In a retrospective cohort of 1107 patients with lymph node invasion following primary prostate cancer treatment, the use of adjuvant radiotherapy was associated with a significant improvement in cancer-specific mortality. 2. Two sub-group of patients: 1) Patients with positive lymph node counts of <2, Gleason score 7-10, pT3b/pT4 stage...
1. In a phase I trial, ODM-201 was well tolerated up to 1800mg per day in prostate cancer patients, without reaching the maximum tolerated dose. 2. In a phase II trial, up to 33% of patients randomized to ODM-201 had a 50% or greater decrease in serum PSA at 12...
1. In men with low-risk prostate cancer undergoing active surveillance, obesity (BMI>30) was significantly associated with pathologic and therapeutic progression after the first confirmatory biopsy. Evidence Rating Level: 3 (Average) Study Rundown: Obesity has previously been associated with increased risk of advanced prostate cancer (PCa), risk of biochemical occurrence, and PCa...
Image: PD 1. The use of 5α-reductase inhibitors (5ARIs) was not associated with increased risk of developing high-grade or lethal prostate cancer. 2. 5ARI use was associated with a decreased incidence of low-risk and overall prostate cancer. Evidence Rating Level: 2 (Good) Study Rundown: 5ARIs have previously been associated with a decreased...
Image: PD 1: Escalated-dose conformal radiotherapy with neoadjuvant androgen deprivation did not increase long-term, overall survival for patients with prostate cancer. 2: The escalated-dose regimen did result in prolonged biochemical progression-free survival, although with increased toxicity.  Evidence Rating: 1 (Excellent) Study Rundown: This study randomized men with T1b-T3a,N0,M0 prostate cancer with PSA levels...
Image: PD 1. Men with localized, non-metastatic prostate cancer who underwent radical prostatectomy demonstrated lower mortality rates compared to treatment with radiotherapy. 2. No treatment advantage between radical prostatectomy versus radiotherapy was observed in metastatic prostate cancer patients. Evidence Rating Level: 2 (Good) Study Rundown: Current mainstay treatment for prostate cancer is surgery...
Image: PD Prostate Histology 1. Serial repeat prostate biopsies may raise the absolute risk of infectious morbidity for patients by up to 15%. 2. Gentamicin is linked to much higher rates of post-procedure infection than flouroquinolones. Evidence Rating: 2 (Good) Study Rundown: Active surveillance with serial ultrasound guided transrectal prostate biopsies has become...
Image: PD 1. The abdominal sacrocolpopexy procedure has been shown to be a promising treatment for pelvic organ prolapse but has increasing complications in the long term. 2. The addition of an anti-incontinence urethropexy procedure to the sacrocolpopexy procedure decreases rates of post-operative stress urinary incontinence. Evidence Rating Level: 1 (Excellent) Study Rundown:...