Tag: vaccine

1. The mRNA-1273 SARS-CoV-2 (COVID-19) vaccine was shown to be safe and immunogenic amongst the 45 COVID-19 negative participants in this phase 1 clinical trial, when compared to serum convalescent plasma 2. Only patients in the highest 2 dosage groups experienced a severe febrile episode after the 2nd dose was...
1. The novel SARS-CoV-2 vaccine, ChAdOx1 nCoV-2, offered a reasonable safety profile with no serious adverse events in first phase 1/2 trial. 2. ChAdOx1 nCoV-2 showed neutralizing antibody responses against SARS-CoV-2 in the majority of patients. Evidence Rating Level: 1 (Excellent) Study Rundown: No vaccines have been approved for the prevention of...
1. The respiratory syncytial virus (RSV) fusion (F) vaccine given to pregnant women did not meet efficacy criteria against RSV-associated lower respiratory tract infection in infants compared to the placebo group, but did show evidence of secondary benefits. 2. The RSV F vaccine was shown to have a safety profile...
1. The full two-dose influenza vaccination series was significantly more effective in preventing future influenza compared to partial vaccination. Evidence Rating Level: 2 (Good) Childhood influenza is a significant health burden, with vaccination being the primary strategy to prevent transmission. Guidelines suggest a primer dose followed by a booster for patients receiving...
1. In this cluster-randomized trial involving Australian adolescents, administration of 4CMenB did not result in lower prevalence of carriage of any disease-causing genogroup of N. meningitidis at 12 months. 2. While 4CMenB may decrease the likelihood of late cases in outbreaks, its ineffectiveness in reducing transmission means that antibiotics remain...
1. In this cluster-randomized trial involving Australian adolescents, administration of 4CMenB did not result in lower prevalence of carriage of any disease-causing genogroup of N. meningitidis at 12 months. 2. While 4CMenB may decrease the likelihood of late cases in outbreaks, its ineffectiveness in reducing transmission means that antibiotics remain...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...
1. In part 1, phase 3 of this randomized controlled trial, the overall vaccine efficacy of TAK-003 (dengue vaccine candidate) was approximately 80% among children ages 4 to 16 years old. 2. In addition, the vaccine increased the number of participants with seropositivity against dengue and showed to have significant...
Long-term impact of an educational antimicrobial stewardship programme in primary care on infections caused by extended-spectrum β-lactamase-producing Escherichia coli in the community: an interrupted time-series analysis. 1. A multi-modal antimicrobial stewardship program in primary care focused on individual educational interviews may improve antibiotic prescription practices and lead to sustained reductions...
1. In this randomized trial involving HIV-negative African adults with latent tuberculosis, vaccination with M72/AS01E provoked an immune response and offered 50% protection against progression to active pulmonary tuberculosis. The rates of serious adverse events, potential immune-mediated diseases, and death were similar between groups. 2. Participants in Kenya and South...