Tag: vaccine

1. In a large Danish cohort study, the measles-mumps-rubella (MMR) vaccine was not significantly associated with autism. 2. There was still no increased risk of autism with vaccination in subgroups of children with various risk factors for autism. Evidence Rating Level: 2 (Good) Study Rundown: In 1998, a controversial in the Lancet reported...
1. This ten-year follow-up study of a randomized controlled trial suggested that intradermal administration of one fifth of the yellow fever vaccine could provide long-term immunity for at least ten years. 2. The participants in this study who received the fractionated dose of yellow fever vaccine did not require...
1. Among dengue-seronegative individuals 2 to 16 years of age, there was a significantly increased risk of hospitalization and severe virologically confirmed dengue (VCD) after vaccination with the tetravalent dengue vaccine (CYD-TDV) compared to dengue-seropositive vaccine recipients and unvaccinated control patients. 2. Vaccination conferred a significantly decreased risk of hospitalization...
1. Zika virus shown to be of moderate to high efficacy in eliminating prenatal infections. 2. Vaccine provides 90% coverage and is targeted for immunization of women aged 9 to 49 years. Evidence Rating Level: 2 (Good) Study Rundown: Zika virus has become an important health challenge since it started to spread...
1. The new adjuvanted herpes zoster subunit vaccine was more efficacious and less expensive for all ages at the price of $280 per series as compared to the single-dose herpes zoster vaccine. 2. It is unclear if a booster of the live attenuated herpes zoster vaccine would be cost-effective, as...
1. Healthy adolescents and young adults treated with the Neisseria meningitidis vaccine MenB-FHbp had increased bactericidal antibody responses (hSBA titer) compared to those treated with control vaccines. 2. More localized injection-site reactions occurred among patients treated with the meningococcal B vaccine compared to control vaccines. Evidence Rating Level: 2 (Good) Study...
  Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults Acute sore throat is one of the most common complaints in patients that present to primary care facilities. Frequently, patients are treated unnecessarily with antibiotics, despite low risks of suppurative complications and limited symptomatic benefit....
1. The herpes zoster subunit vaccine (HZ/su) demonstrated age-independent efficacy and significantly reduced the incidence of herpes zoster and postherpetic neuralgia (PHN) in adults over age 70. 2. Compared to placebo, the HZ/su vaccine was not associated with an increase in serious adverse events or potential immune-mediated diseases. Evidence Rating Level:...
1. In children aged 6 to 14 weeks, rates of hospitalization from intussusception post-vaccination with the rotavirus vaccine were significantly elevated by 46% to 101%. 2. No change was observed in the hospitalization rate from intussusception in children 15 to 34 weeks of age. Evidence Rating Level: 2 (Good) Study Rundown: Recent...
1. In response to a meningococcal B outbreak at a US university in 2013 and 2014, the FDA approved the use of a recombinant meningoccal B vaccine (4CMenB) before licensure. 2. Among a sample of students who revived two doses of the 4CMenB vaccine, nearly one-third were found to be...