Tag: vaccine

1. From this small randomized, double-blinded, placebo controlled trial, two novel adenovirus-based human immunodeficiency virus (HIV) vaccinations were safe, well-tolerated, and immunogenic. 2. Anti-HIV antibody responses were observed when participants received the same vaccine as a priming dose and booster, or when patients received first one and then the other...
1. From a model, the incremental cost-effectiveness ratio between Herpes zoster vaccination and no vaccination at age 50 years was over $300,000 per QALY. 2. At a willingness to pay threshold of $100,000 per QALY, the probability that vaccination would be cost-effective was only 3%. Evidence Rating Level: 2 (Good) Study Rundown:...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. A Randomized, Controlled Trial of an Aerosolized Vaccine against Measles While an effective injected measles vaccine has been available since 1963, world-wide goals to eliminate measles seek to develop low cost, less...
1. In this study of children with older siblings with or without an autism spectrum disorder (ASD), there was no increased risk of development of an autism spectrum disorder following receipt of the measles-mumps-rubella (MMR) vaccine regardless of their older sibling’s ASD status. 2. Among children with older siblings with...
1. In this report of a 44-year-old male exposed to Ebola virus through a needle stick in Sierra Leone, vaccination with an experimental vaccine (VZVDG-ZEBOV) was effective in preventing Ebola virus infection. 2. Laboratory analysis indicated an innate and adaptive immune response after administration of the VZVDG-ZEBOV vaccine. Evidence Rating Level:...
1. In a phase II trial of 90 patients with metastatic pancreatic adenocarcinoma, the combination of two cancer vaccines, Cy/GVAX and CRS-207, was associated with increased overall survival compared to Cy/GVAX alone. Evidence Rating Level: 1 (Excellent)       Study Rundown: Previous studies have demonstrated the use of cancer vaccines...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events Decreased sodium intake is associated with a modest decrease in blood pressure, but it is unclear whether this translates to a decrease in...
1. High-dose influenza vaccination significantly reduced the incidence of influenza illness in adults 65 years of age or older when compared with the standard-dose vaccine.  Evidence Rating Level: 1 (Excellent) Study Rundown: Seasonal influenza remains a major cause of morbidity and mortality, particularly amongst individuals 65 years of age or older....
1. N. meningitidis is a bacterium responsible for meningitis, bacteremia, and pneumonia, with potentially lethal and long term sequelae. 2. The American Academy of Pediatrics (AAP) has adjusted its vaccination guidelines to include two newly licensed conjugate vaccines, Hib-MenCY-TT and MenACWY-CRM, in an effort to address immunization of younger children...
1. A recombinant live, attenuated, tetravalent vaccine was effective against dengue fever in children aged 2-14 years in endemic countries in the Asia-Pacific region.  2. The serious adverse event (mainly infections and injuries) rate was approximately 1% within 28 days of vaccination. There was one vaccine-related case of acute disseminated...