Tag: Zika

Association of HLA antigen mismatch with risk of developing skin cancer after solid-organ transplant Immunosuppressive agents reduce the risk of graft rejection in solid-organ transplant recipients. However, immunosuppressive regimens are not without risks, increasing the risk of cancer, a major source of morbidity and mortality. In particular, the risk of...
1. Zika virus shown to be of moderate to high efficacy in eliminating prenatal infections. 2. Vaccine provides 90% coverage and is targeted for immunization of women aged 9 to 49 years. Evidence Rating Level: 2 (Good) Study Rundown: Zika virus has become an important health challenge since it started to spread...
1. In this prospective cohort study from Brazil, most patients admitted with new parainfectious/neuroinflammatory conditions including Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis had molecular or serologic evidence of recent Zika Virus (ZIKV) infection. 2. Rates of admission for neuroinflammatory conditions were higher in Brazil during the study period than...
1. Infants born to symptomatic Zika-positive mothers demonstrated higher rates of fetal death, fetal growth restriction and central nervous system abnormalities. 2. Zika-positive pregnant women were more likely to present with maculopapular pruritic rash and conjunctival injection compared to Zika-negative pregnant women. Evidence Rating Level: 2 (Good) Study Rundown: Zika virus...
1. Antibodies were isolated from patients with prior Zika virus infection and one specific antibody, ZIKV-117, decreased fetal transmission of Zika virus as well as viral replication in mice. 2. ZIKV-117 was efficacious at neutralizing the Zika virus when administered prophylactically and after virus exposure. Evidence Rating Level: 2 (Good) Study...
1. Exanthema, fever, and arthralgia comprise the most common symptoms of Zika virus disease. 2. Considerable risk for major complications exists with first trimester transmission of Zika virus to pregnant women Evidence Rating Level: 2 (Good) Study Rundown: Transmitted primarily by Aedes mosquitos, Zika virus disease has continued to spread geographically throughout...
Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma Daratumumab is a human monoclonal antibody that has shown efficacy and safety in phase 1 and 2 trials for patients with refractory or relapsed multiple myeloma. This phase 3 randomized trial investigated daratumumab as an adjunct to lenalidomide and dexamethasone in 569 patients...
  1. A DNA vaccine and a purified inactivated vaccine (PIV) conferred complete immunity in mice challenged with the Zika virus (ZIKV). 2. Purified IgG antibodies from the serum of DNA-vaccinated mice provided protection against ZIKV in naïve mice in a dose-dependent manner. Evidence Rating Level: 2 (Good) Study Rundown: Infection with ZIKV,...
  1. A paper-based, rapid, and inexpensive assay detected genetic components of Zika virus at concentrations akin to those in human saliva and serum. 2. Plasma samples from a viremic rhesus macaque infected with Zika virus were detected by the assay, demonstrating its suitability for clinical diagnosis. Evidence Rating Level: 1 (Excellent)...
1. In a case series of 23 infants with Zika virus infection, computed tomography (CT) of the head demonstrated a high prevalence of punctate intracranial calcifications, primarily within the frontal and parietal lobes with associated severe lateral ventriculomegaly. 2. Other common, non-specific brain findings include global hypogyration, cerebellar hypoplasia, and...